Stiripentol-d9 (CAS 1185239-64-8)
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Stiripentol-d9 is a compound that functions as an inhibitor of cytochrome P450 enzymes, specifically CYP3A4 and CYP2C19. It acts by binding to the active site of these enzymes, preventing the metabolism of substrates. This inhibition results in an increase in the plasma concentration of compounds that are metabolized by CYP3A4 and CYP2C19. Stiripentol-d9 may be able modulate the activity of gamma-aminobutyric acid (GABA) receptors, leading to an enhancement of GABAergic neurotransmission. This modulation of GABA receptors contributes to the anticonvulsant effects of Stiripentol-d9. At the molecular level, Stiripentol-d9 interacts with specific amino acid residues within the binding site of CYP3A4 and CYP2C19, leading to a decrease in their enzymatic activity. Its interaction with GABA receptors involves allosteric modulation, leading to an increase in the inhibitory effects of GABA on neuronal excitability.
Stiripentol-d9 (CAS 1185239-64-8) References
- Simultaneous determination of 24 antiepileptic drugs and their active metabolites in human plasma by UHPLC-MS/MS. | Jiang, R., et al. 2023. J Pharm Biomed Anal. 232: 115437. PMID: 37146498
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stiripentol-d9, 1 mg | sc-220134 | 1 mg | $453.00 |