Molecular structure of SR 1001, CAS Number: 1335106-03-0
SR 1001 (CAS 1335106-03-0)
Alternate Names:
N-(5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)sulfamoyl)-4-methylthiazol-2-yl)acetamide
CAS Number:
1335106-03-0
Molecular Weight:
477.4
Molecular Formula:
C15H13F6N3O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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SR 1001 (CAS 1335106-03-0) References
- Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. | Solt, LA., et al. 2011. Nature. 472: 491-4. PMID: 21499262
- Targeting Th17-IL-17 Pathway in Prevention of Micro-Invasive Prostate Cancer in a Mouse Model. | Zhang, Q., et al. 2017. Prostate. 77: 888-899. PMID: 28240383
- Development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for quantification of SR1001, an inverse agonist of retinoid-related orphan receptors, and its application to pharmacokinetic studies in streptozotocin-induced diabetic mice. | Lin, C., et al. 2017. J Pharm Biomed Anal. 143: 94-100. PMID: 28578255
- Topical ROR Inverse Agonists Suppress Inflammation in Mouse Models of Atopic Dermatitis and Acute Irritant Dermatitis. | Dai, J., et al. 2017. J Invest Dermatol. 137: 2523-2531. PMID: 28774591
- Protective effects of resveratrol and SR1001 on hypoxia-induced pulmonary hypertension in rats. | Li, C., et al. 2020. Clin Exp Hypertens. 42: 519-526. PMID: 31973589
- Melatonin inhibits apoptosis in mouse Leydig cells via the retinoic acid-related orphan nuclear receptor α/p53 pathway. | Li, Z., et al. 2020. Life Sci. 246: 117431. PMID: 32061868
- RORγt Inhibitor-SR1001 Halts Retinal Inflammation, Capillary Degeneration, and the Progression of Diabetic Retinopathy. | Zapadka, TE., et al. 2020. Int J Mol Sci. 21: PMID: 32429598
- RORγt inhibitor SR1001 alleviates acute pancreatitis by suppressing pancreatic IL-17-producing Th17 and γδ-T cells in mice with ceruletide-induced pancreatitis. | Wang, J., et al. 2021. Basic Clin Pharmacol Toxicol. 129: 357-368. PMID: 34384137
- Treatment with butyrate alleviates dextran sulfate sodium and Clostridium difficile-induced colitis by preventing activity of Th17 cells via regulation of SIRT1/mTOR in mice. | Wang, S., et al. 2023. J Nutr Biochem. 111: 109155. PMID: 36162566
- Fasudil and SR1001 synergistically protect against sepsis-associated pancreatic injury by inhibiting RhoA/ROCK pathway and Th17/IL-17 response. | Liu, P., et al. 2023. Heliyon. 9: e20118. PMID: 37809525
Inhibitor of:
c-Fos, GPR43, NR3B, PRC, RORα, and RORγ.Activator of:
RORβ.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SR 1001, 5 mg | sc-507320 | 5 mg | $150.00 |