Sparfloxacin CAS: 110871-86-8
MF: C19H22F2N4O3
MW: 392.40
A broad spectrum fluoroquinolone antibiotic.

Sparfloxacin (CAS 110871-86-8)

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Sparfloxacin is rated 5.0 out of 5 by 1.
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Nomes alternativos: Zagam
Aplicação Sparfloxacin is a broad spectrum fluoroquinolone antibiotic
Numero VAT: 110871-86-8
Privada: ≥98%
Peso Molecular: 392.40
Separar por Funcao: C19H22F2N4O3
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
DISCOUNT: Bulk orders of Chemicals totaling $1,000 or more receive a 5% discount.
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Sparfloxacin is a fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Mycobacterium tuberculosis. Shows photosensitizing effects. Sparfloxacin is an inhibitor of Topo II.


Referencias

1. In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone: S. Nakamura, et al.; Antimicrob. Agents Chemother. 33, 1167 (1989). 2. Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, inc

Estado físico :
Solid
envie :
Soluble in water (<1 mg/ml), 100% ethanol, chloroform, methanol, and DMSO (9 mg/ml).
Manutencao :
Store at -20° C
Ponto de fusão :
265° C
Ponto de fervura :
~640.4° C at 760 mmHg (Predicted)
Densidade :
~1.4 g/cm3 (Predicted)
Indice de produtos :
n20D 1.63 (Predicted)
IC50 :
DNA gyrase: IC50 = 0.64 µM (Escherichia coli K-12); Nucleic Acid: IC50 = 17.5 µM; HERG: IC50 = 18.20 µM (human); V79: IC50 = 94.2 µM (Cricetulus griseus)
Data ki :
HERG: Ki= 38.62 µM (human)
Valores de pK :
pKa: 6.42 (Predicted), pKb: 8.59 (Predicted)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
2
RTECS :
VB1986500
PubChem CID :
Indice de produtos :
14: 8735
Numero de FAX :
MFCD00869619
Registro Beilstein :
9170271
SMILES :
C[[email protected]@H]1CN(C[[email protected]@H](N1)C)C2=C(C3=C(C(=C2F)N)C(=O)C(=CN3C4CC4)C(=O)O)F

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