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SODD Antibody (C-12) is an IgG2b κ mouse monoclonal SODD antibody (also designated SODD antibody) that detects the SODD protein of human origin by WB, IP, IF and ELISA. SODD Antibody (C-12) is available as both the non-conjugated anti-SODD antibody form, as well as multiple conjugated forms of anti-SODD antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The cytokine TNF (tumor necrosis factor) signals through the TNF-R1 receptor to activate various cellular pathways, including apoptosis and NFkB activation. TNF binding induces receptor aggregation, resulting in the recruitment of TRADD, FADD, TRAF2 and RIP to the intracellular "death" domain of the receptor complex, which in turn activates signaling pathways including apoptosis and NFkB activation. SODD, for silencer of death domains, was found to be associated with the intracellular "death" domain of TNF-R1 in the absence of TNF stimulation. TNF treatment results in the release of SODD from TNF-R1, allowing the recruitment of TRADD and TRAF2 to the receptor complex. Thus, SODD may play a role in preventing spontaneous signaling by death-domain receptors, in the absence of ligand.
Alexa Fluor® é uma marca comercial da Molecular Probes Inc., OR., EUA
LI-COR® e Odyssey® são marcas registadas da LI-COR Biosciences
Informacoes sobre ordens
Nome do Produto | Numero de Catalogo | UNID | Preco | Qde | FAVORITOS | |
SODD Anticorpo (C-12) | sc-166581 | 200 µg/ml | $316.00 | |||
Pacote do SODD (C-12): m-IgGκ BP-HRP | sc-521665 | 200 µg Ab, 40 µg BP | $354.00 | |||
Pacote do SODD (C-12): m-IgG2b BP-HRP | sc-548950 | 200 µg Ab; 10 µg BP | $354.00 | |||
SODD Anticorpo (C-12) AC | sc-166581 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SODD Anticorpo (C-12) HRP | sc-166581 HRP | 200 µg/ml | $316.00 | |||
SODD Anticorpo (C-12) FITC | sc-166581 FITC | 200 µg/ml | $330.00 | |||
SODD Anticorpo (C-12) PE | sc-166581 PE | 200 µg/ml | $343.00 | |||
SODD Anticorpo (C-12) Alexa Fluor® 488 | sc-166581 AF488 | 200 µg/ml | $357.00 | |||
SODD Anticorpo (C-12) Alexa Fluor® 546 | sc-166581 AF546 | 200 µg/ml | $357.00 | |||
SODD Anticorpo (C-12) Alexa Fluor® 594 | sc-166581 AF594 | 200 µg/ml | $357.00 | |||
SODD Anticorpo (C-12) Alexa Fluor® 647 | sc-166581 AF647 | 200 µg/ml | $357.00 | |||
SODD Anticorpo (C-12) Alexa Fluor® 680 | sc-166581 AF680 | 200 µg/ml | $357.00 | |||
SODD Anticorpo (C-12) Alexa Fluor® 790 | sc-166581 AF790 | 200 µg/ml | $357.00 |