SETD4 Antibody (F-3): sc-514060
- SETD4 Antibody (F-3) is a mouse monoclonal IgG1 κ SETD4 antibody, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 24-51 near the N-terminus of SETD4 of human origin
- SETD4 Antibody (F-3) is recommended for detection of SETD4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SETD4 Antibody (F-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SETD4 Antibody (F-3) for WB applications. These reagents are now offered in bundles with SETD4 Antibody (F-3) (see ordering information below).
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SETD4 Antibody (F-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects SETD4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SETD4 (F-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. SETD4 protein consists of 440 amino acids and features a single SET domain, playing a crucial role in regulating gene expression and chromatin dynamics, making SETD4 essential for cellular processes such as differentiation and development. SETD4 is involved in methylation of histone proteins, a key post-translational modification that influences chromatin structure and function. This modification is vital for proper regulation of gene expression, and dysregulation of SETD4 has been implicated in various diseases, including certain cancers and neurodegenerative disorders. SETD4 gene is located on human chromosome 21, which is associated with several genetic conditions, including Down syndrome. Understanding SETD4 function and regulation is important for elucidating SETD4′s role in health and disease, making anti-SETD4 antibody (F-3) a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SETD4 Antibody (F-3) References:
- Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution. | Müller, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 206-11. PMID: 10618396
- Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart. | Mao, R., et al. 2005. Genome Biol. 6: R107. PMID: 16420667
- BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome. | Sun, X., et al. 2006. FASEB J. 20: 1369-76. PMID: 16816112
- The discovery and mapping to chromosome 21 of the Alzheimer's amyloid gene: history revised. | Robakis, NK. 2006. J Alzheimers Dis. 10: 453-5. PMID: 17183160
- Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts. | Peterson, LF., et al. 2007. Blood. 110: 799-805. PMID: 17412887
- Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes. | Aït Yahya-Graison, E., et al. 2007. Am J Hum Genet. 81: 475-91. PMID: 17701894
- DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease. | Ryoo, SR., et al. 2007. J Biol Chem. 282: 34850-7. PMID: 17906291
- Exclusion of KCNE1 (IsK) as a candidate gene for Jervell and Lange-Nielsen syndrome. | Tesson, F., et al. 1996. J Mol Cell Cardiol. 28: 2051-5. PMID: 8899564
- IsK and KvLQT1: mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome. | Tyson, J., et al. 1997. Hum Mol Genet. 6: 2179-85. PMID: 9328483
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SETD4 Antibody (F-3) | sc-514060 | 200 µg/ml | $322.00 | |||
SETD4 Antibody (F-3): m-IgG Fc BP-HRP Bundle | sc-531018 | 200 µg Ab; 10 µg BP | $361.00 | |||
SETD4 Antibody (F-3): m-IgGκ BP-HRP Bundle | sc-524592 | 200 µg Ab, 40 µg BP | $361.00 | |||
SETD4 Antibody (F-3): m-IgG1 BP-HRP Bundle | sc-544361 | 200 µg Ab; 20 µg BP | $361.00 | |||
SETD4 Antibody (F-3) AC | sc-514060 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SETD4 Antibody (F-3) HRP | sc-514060 HRP | 200 µg/ml | $322.00 | |||
SETD4 Antibody (F-3) FITC | sc-514060 FITC | 200 µg/ml | $336.00 | |||
SETD4 Antibody (F-3) PE | sc-514060 PE | 200 µg/ml | $349.00 | |||
SETD4 Antibody (F-3) Alexa Fluor® 488 | sc-514060 AF488 | 200 µg/ml | $364.00 | |||
SETD4 Antibody (F-3) Alexa Fluor® 546 | sc-514060 AF546 | 200 µg/ml | $364.00 | |||
SETD4 Antibody (F-3) Alexa Fluor® 594 | sc-514060 AF594 | 200 µg/ml | $364.00 | |||
SETD4 Antibody (F-3) Alexa Fluor® 647 | sc-514060 AF647 | 200 µg/ml | $364.00 | |||
SETD4 Antibody (F-3) Alexa Fluor® 680 | sc-514060 AF680 | 200 µg/ml | $364.00 | |||
SETD4 Antibody (F-3) Alexa Fluor® 790 | sc-514060 AF790 | 200 µg/ml | $364.00 | |||
SETD4 (F-3) Neutralizing Peptide | sc-514060 P | 100 µg/0.5 ml | $69.00 |