Septin 8 Antibody (G-12): sc-514436

Septin 8 Antibody (G-12) is a mouse monoclonal IgG2b antibody that detects Septin 8 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Septin 8 is a 508 amino acid protein that plays a crucial role in various cellular processes, including vesicle trafficking, apoptosis, and cytokinesis, making it essential for maintaining cellular integrity and function. Septin 8 is predominantly expressed in the brain, cardiovascular regions, prostate, testis, and ovary, highlighting its significance in both neural and reproductive health. Notably, Septin 8 interacts with other septins, such as Septin 5, and cell division cycle related-1 (CDCrel-1), which suggests involvement in complex protein networks that regulate cell division and signaling pathways. The ability of Septin 8 to form oligomeric structures allows for dynamic scaffold formation, contributing to cytoskeleton organization and facilitating cellular responses to various stimuli. Furthermore, Septin 8, along with Septin 4 and Septin 5, has been implicated in platelet biology, where these proteins surround alpha-granules, indicating a potential role in hemostasis and thrombosis. anti-Septin 8 antibody (G-12) is an invaluable tool for researchers investigating the multifaceted roles of septins in health and disease.

The preferred Septin 8 antibody is Septin 8 Antibody (C-5): sc-390074.