Anti-SENP1 Anticorpo C-12é um anticorpo monoclonal produzido em camundongo IgG1 κ SENP1 anticorpo, citado em 15 publicações, fornecido em 200 µg/ml
raised against amino acids 361-425 mapping within an internal region of SENP1 of human origin
Anti-SENP1 Anticorpo (C-12) é recomendado para a detecção de SENP1 de mouse, rat e human origem em WB, IP, IF e ELISA
Anti-SENP1 Antibody (C-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Entre em contato conosco e receba GRATUITAMENTE um amostra de 10 µg de SENP1 (C-12): sc-271360.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SENP1 Antibody (C-12) for WB applications. These reagents are now offered in bundles with SENP1 Antibody (C-12) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
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SENP1 Antibody (C-12) is a high quality monoclonal SENP1 antibody suitable for the detection of the SENP1 protein of mouse, rat and human origin. SENP1 Antibody (C-12) is available as both the non-conjugated anti-SENP1 antibody form, as well as multiple conjugated forms of anti-SENP1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins, including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the "GG" region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates. HIPK2 is a desumoylation target for SENP1 which shuttles between the cytoplasm and the nucleus. Mutation analyses reveal that SENP1 contains the nuclear export sequence (NES) within the extreme carboxyl-terminal region, and SENP1 is exported to the cytoplasm in a NES-dependent manner. SENP2 has been implicated as a downregulator of CTNNB1 levels and may therefore be a modulator of the Wnt pathway. SUMO protease SENP3 reverses the sumoylation of MEF2 to augment its transcriptional and myogenic activities. SENP5 localizes to the nucleolus and preferentially processes SUMO-3. It is thought to play a role in mitosis and/or cytokinesis. SENP6 localizes to the cytoplasm and releases SUMO-1. Expression of SENP6 is higher in reproductive organs, indicating that it may mediate processes related to reproduction. SENP8 is involved in the release of sentrins.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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