RP105 Antibody (3H1961): sc-71967

RP105 Antibody (3H1961) is a rat monoclonal IgG2a antibody that detects RP105 in mouse samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-RP105 antibody (3H1961) recognizes a critical B-cell surface molecule that plays a vital role in transmitting growth-promoting signals, influencing the life and death decisions of B cells. RP105 is characterized by tandem repeats of a leucine-rich motif in the extracellular domain, which are essential for mediating protein-protein interactions crucial for B cell activation and function. Notably, the amino acid sequence of human RP105 exhibits a high degree of homology with mouse RP105, sharing 74% identity, which underscores the evolutionary conservation of its function. The expression of RP105 is significantly enhanced in the presence of MD1, although specifically restricted to CD19-positive B cells, highlighting its importance in the maturation and regulation of these immune cells. RP105 is predominantly expressed on mature B cells located in the mantle zones of lymphoid follicles, with minimal expression observed in germinal centers, indicating its role in the early stages of B cell development and response. RP105 monoclonal antibody (3H1961) serves as an invaluable tool for researchers studying B cell biology and related immunological processes.

The preferred RP105 antibody is RP105 Antibody (RP/14): sc-13592.