PRMT2 Antibody (C-3): sc-514133

PRMT2 Antibody (C-3) is a mouse monoclonal IgG1 antibody that detects PRMT2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRMT2, a 433 amino acid protein encoded by the human gene PRMT2, plays a crucial role in the regulation of cellular transcription and apoptosis. As a member of the protein arginine N-methyltransferase family, PRMT2 is involved in the post-translational methylation of arginine residues, which is essential for modifying chromatin structure and influencing gene expression. Notably, PRMT2 contains a highly conserved S-adenosylmethionine-binding domain that allows PRMT2 to inhibit NF-kappaB-dependent transcription, a key pathway in inflammation and immune response. By blocking the nuclear export of IkappaB-alpha, PRMT2 increases nuclear concentration, thereby reducing NF-kappaB DNA binding and promoting apoptosis in response to cytokines or cytotoxic drugs. This regulatory mechanism highlights PRMT2′s importance in maintaining cellular homeostasis and potential implications in cancer and other diseases where NF-kappaB signaling is dysregulated.

The preferred PRMT2 antibody is PRMT2 Antibody (B-11): sc-393254.