PCNA Anticorpo (F-2): sc-25280
- PCNA(F-2) is a mouse monoclonal IgG2a κ, cited in 391 publications, provided at 200 µg/ml
- Anti-PCNA(F-2) is recommended for detection in mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anticorpo anti-PCNA O anticorpo anti-PCNA (F-2) está disponível conjugado com agarose para IP; HRP para WB, IHC(P) e ELISA; e com fioeritrina ou FITC para IF, IHC(P) e FCM
- também disponível conjugado com Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 ou Alexa Fluor® 647 para WB (RGB), IF, IHC(P) e FCM, e para utilização com sistemas de imagiologia fluorescente RGB, tais como iBright™ FL1000, FluorChem™, Typhoon, Azure e outros sistemas comparáveis
- também disponível conjugado com Alexa Fluor® 680 ou Alexa Fluor® 790 para WB (NIR), IF e FCM; para utilização com sistemas de deteção de infravermelhos próximos (NIR), tais como LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure e outros sistemas comparáveis
- Entre em contato conosco e receba GRATUITAMENTE um amostra de 10 µg de PCNA (F-2): sc-25280.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP e m-IgGκ BP-HRP são os reagentes de deteção secundários preferidos para PCNA Anticorpo (F-2) para aplicações WB and IHC(P). Estes reagentes são agora oferecidos em conjuntos com PCNA Anticorpo (F-2) (ver informações para encomenda abaixo).
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Proliferating Cell Nuclear Antigen, also known as cyclin, is a highly conserved nuclear protein that plays a critical role in DNA replication and repair. Functioning as a sliding clamp, Proliferating Cell Nuclear Antigen forms a homotrimeric ring around DNA, facilitating the processivity of DNA polymerases delta (δ) and epsilon (ε) during replication. This allows Proliferating Cell Nuclear Antigen to act as a scaffold for recruiting various proteins that are key players in DNA repair, chromatin remodeling, and the regulation of the cell cycle. Proliferating Cell Nuclear Antigen expression peaks during the S phase of the cell cycle, making it a useful marker for cell proliferation studies. Proliferating Cell Nuclear Antigen is widely used in research to investigate the mechanisms governing DNA replication, genome stability, and cellular responses to DNA damage. Playing a crucial role in various DNA repair pathways, such as nucleotide excision repair, base excision repair, and mismatch repair, Proliferating Cell Nuclear Antigen interacts with key proteins to fix DNA lesions and correct base-pair mismatches after replication. Proliferating Cell Nuclear Antigen is involved in chromatin assembly and nucleosome formation, which are critical for maintaining genomic integrity during replication and repair processes. Post-translational modifications, such as ubiquitination and sumoylation, play a significant role in regulating Proliferating Cell Nuclear Antigen’s functions, particularly in DNA damage tolerance pathways like translesion synthesis and template switching. These modifications ensure that Proliferating Cell Nuclear Antigen can function effectively even when the cell encounters damaged DNA, aiding in genome maintenance. In cancer research, Proliferating Cell Nuclear Antigen is particularly important due to its overexpression in highly proliferative tumor cells. The high proliferation rates of cancer cells make Proliferating Cell Nuclear Antigen a significant biomarker for both diagnosis and prognosis. Proliferating Cell Nuclear Antigen also serves as a promising target for developing novel cancer therapies, as modulating Proliferating Cell Nuclear Antigen or its interactions could inhibit tumor growth.
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
Informacoes sobre ordens
| Nome do Produto | Numero de Catalogo | UNID | Preco | Qde | FAVORITOS | |
PCNA Anticorpo (F-2) | sc-25280 | 200 µg/ml | $316.00 | |||
Pacote do PCNA (F-2): m-IgG Fc BP-HRP | sc-528392 | 200 µg Ab; 10 µg BP | $354.00 | |||
Pacote do PCNA (F-2): m-IgGκ BP-HRP | sc-520762 | 200 µg Ab, 40 µg BP | $354.00 | |||
Pacote do PCNA (F-2): m-IgG2a BP-HRP | sc-547083 | 200 µg Ab; 10 µg BP | $354.00 | |||
PCNA Anticorpo (F-2) AC | sc-25280 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PCNA Anticorpo (F-2) HRP | sc-25280 HRP | 200 µg/ml | $316.00 | |||
PCNA Anticorpo (F-2) FITC | sc-25280 FITC | 200 µg/ml | $330.00 | |||
PCNA Anticorpo (F-2) PE | sc-25280 PE | 200 µg/ml | $343.00 | |||
PCNA Anticorpo (F-2) Alexa Fluor® 488 | sc-25280 AF488 | 200 µg/ml | $357.00 | |||
PCNA Anticorpo (F-2) Alexa Fluor® 546 | sc-25280 AF546 | 200 µg/ml | $357.00 | |||
PCNA Anticorpo (F-2) Alexa Fluor® 594 | sc-25280 AF594 | 200 µg/ml | $357.00 | |||
PCNA Anticorpo (F-2) Alexa Fluor® 647 | sc-25280 AF647 | 200 µg/ml | $357.00 | |||
PCNA Anticorpo (F-2) Alexa Fluor® 680 | sc-25280 AF680 | 200 µg/ml | $357.00 | |||
PCNA Anticorpo (F-2) Alexa Fluor® 790 | sc-25280 AF790 | 200 µg/ml | $357.00 |