PCNA Inhibitors
PCNA inhibitors belong to a distinctive chemical class of compounds that specifically target and interact with Proliferating Cell Nuclear Antigen (PCNA), a crucial protein involved in DNA replication and repair processes. PCNA, also known as the DNA sliding clamp, plays a vital role in coordinating the activity of various enzymes responsible for DNA synthesis, ensuring accurate replication and maintaining genomic integrity. The inhibitors designed to interact with PCNA are carefully crafted to disrupt the protein's normal functioning, thereby modulating DNA replication and repair pathways in a controlled manner.
By interfering with PCNA's function, these inhibitors may help researchers gain valuable insights into the fundamental mechanisms of DNA replication and repair, offering a means to study cellular processes related to genome stability and cellular proliferation. Their unique mode of action and specific targeting of PCNA make these inhibitors valuable tools for scientific research in the fields of molecular biology, genetics, and biochemistry.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $25.00 $36.00 $66.00 $76.00 $229.00 $525.00 $964.00 | 12 | |
Tannic acid is a naturally occurring polyphenol compound found in plants. It has been shown to inhibit PCNA in various research applications. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine (CAS 2086-83-1) is a naturally occurring isoquinoline alkaloid known to act as an inhibitor of proliferating cell nuclear antigen (PCNA). PCNA is essential for DNA replication and repair processes. Berberine interferes with the interaction between PCNA and other proteins involved in DNA synthesis, potentially disrupting cellular proliferation by affecting the function of PCNA in maintaining DNA integrity during replication. | ||||||
Mangostin | 6147-11-1 | sc-211773 | 10 mg | $245.00 | ||
Mangostin (CAS 6147-11-1) is a natural xanthone compound that functions as an inhibitor of proliferating cell nuclear antigen (PCNA). PCNA plays a crucial role in DNA replication and repair processes, acting as a scaffold for various proteins involved in these pathways. Mangostin is known to bind to PCNA, interfering with its ability to assist in DNA synthesis and repair, thereby impacting cellular proliferation and the integrity of DNA replication machinery in scientific studies. | ||||||
Rutin trihydrate | 250249-75-3 | sc-204897 sc-204897A sc-204897B | 5 g 50 g 100 g | $56.00 $71.00 $124.00 | 7 | |
Rutin is a flavonoid commonly found in many fruits and vegetables. It has been investigated for its ability to inhibit PCNA and its potential as an anti-cancer agent in research. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic Acid (CAS 77-52-1) is a naturally occurring pentacyclic triterpenoid that acts as an inhibitor of proliferating cell nuclear antigen (PCNA). PCNA is a critical protein in DNA replication and repair. Ursolic Acid has been shown to interact with PCNA, inhibiting its function and disrupting the protein interactions essential for DNA synthesis. This inhibition is of interest in research studying cellular processes related to DNA replication and repair mechanisms. | ||||||
Rosmarinic Acid | 20283-92-5 | sc-202796 sc-202796A | 10 mg 50 mg | $57.00 $107.00 | 4 | |
This phenolic compound is present in herbs like rosemary and has shown PCNA inhibitory effects, making it an interesting target for cancer research. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid is a polyphenol found in various fruits and nuts. It has been studied for its ability to inhibit PCNA and its potential anti-cancer properties in a research setting. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin (CAS 458-37-7) is a bioactive compound that acts as an inhibitor of the Proliferating Cell Nuclear Antigen (PCNA) protein, a key regulator in DNA replication and repair. It interacts with PCNA by disrupting its function in the DNA synthesis process, which affects the protein′s role in cell cycle progression. This interference highlights Curcumin′s utility in scientific research for studying cellular mechanisms involving PCNA-dependent pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is an isoflavone found in soybeans and other legumes. It has been studied for its PCNA inhibitory effects. | ||||||