Pbx 1/2/3/4 Antibody (E-12): sc-48423

Pbx 1/2/3/4 Antibody (E-12) is a mouse monoclonal IgG1 antibody that detects Pbx 1/2/3/4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pbx proteins are crucial members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins, playing significant roles in developmental processes and gene regulation. Pbx 1, Pbx 2, and Pbx 3 share a high degree of sequence identity, particularly in their homeobox domains, which is essential for their function as transcription factors that regulate the expression of target genes involved in cell differentiation and proliferation. The structural integrity of these proteins is vital, as their homeodomain allows for specific binding to DNA, influencing the transcriptional activity of various genes. Pbx 4 is uniquely expressed in the testis, particularly in spermatocytes during the pachytene stage of meiosis, highlighting the importance of Pbx proteins in both somatic and germ cell development. Anti-Pbx 1/2/3/4 antibody (E-12) is an invaluable tool for researchers studying the roles of these proteins in normal physiology and disease states, including their involvement in human pre-B cell acute leukemias associated with chromosomal rearrangements.

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Pbx 1/2/3/4 Antibody (E-12) References:

1. The TALE homeodomain protein Pbx2 is not essential for development and long-term survival.  |  Selleri, L., et al. 2004. Mol Cell Biol. 24: 5324-31. PMID: 15169896
2. Coexpression of HOXA6 and PBX2 promotes metastasis in gastric cancer.  |  Lin, J., et al. 2021. Aging (Albany NY). 13: 6606-6624. PMID: 33535170
3. Identifying the Potential Roles of PBX4 in Human Cancers Based on Integrative Analysis.  |  Song, Y. and Ma, R. 2022. Biomolecules. 12: PMID: 35740947
4. Phosphorylation of PBX2, a novel downstream target of mTORC1, is determined by GSK3 and PP1.  |  Wada, R., et al. 2023. J Biochem. 173: 129-138. PMID: 36477205
5. LncRNA LINC00885 promotes bladder cancer progression by targeting the miR-98-5p/PBX3 axis.  |  Xia, Z., et al. 2023. Cell Mol Biol (Noisy-le-grand). 69: 163-168. PMID: 37300672
6. PBX3 as a biomarker for the early diagnosis and prediction of prognosis of glioma.  |  Pan, C., et al. 2024. PLoS One. 19: e0293647. PMID: 38324550
7. PBX1 as a novel master regulator in cancer: Its regulation, molecular biology, and therapeutic applications.  |  Kao, TW., et al. 2024. Biochim Biophys Acta Rev Cancer. 1879: 189085. PMID: 38341110
8. Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia.  |  Blumel, L., et al. 2024. Haematologica. 109: 2290-2296. PMID: 38426288
9. Lupus susceptibility gene Pbx1 controls the development, stability, and function of regulatory T cells via Rtkn2 expression.  |  Choi, SC., et al. 2024. Sci Adv. 10: eadi4310. PMID: 38536923
10. The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins.  |  Neuteboom, ST., et al. 1995. Proc Natl Acad Sci U S A. 92: 9166-70. PMID: 7568094

The preferred Pbx 1b antibody is Pbx 1b Antibody (41.1): sc-101852.