p19 INK4D/CDKN2D Anticorpo A-4é um anticorpo monoclonal produzido em camundongo IgG3 (kappa light chain) fornecido em 200 µg/ml
específico para um epítopo mapeado entre os aminoácidos135-154 no C-terminus de p19 de mouse origem
recomendado para a detecção de p19 de mouse e rat origem em
m-IgG3 BP-HRP is the preferred secondary detection reagent for p19 INK4D/CDKN2D Antibody (A-4) for WB applications. This reagent is now offered in a bundle with p19 INK4D/CDKN2D Antibody (A-4) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Clique na imagem ou no botão para ampliar a imagem
The normal progression of cells through the cell cycle is under the control of the cyclin dependent protein kinases Cdk4 and Cdk6, which are subject to inhibition by the mitotic inhibitory protein, p16 INK4A. Isolated members of the p16 INK4A family have been designated p15 INK4B, p18 INK4C and p19 INK4D. p15 INK4B expression is upregulated approximately 30-fold in TGFβ-treated human keratinocytes, suggesting that p15 INK4B may function as an effector of TGFβ-mediated cell cycle arrest through inhibition of Cdk4 and Cdk6 kinases. The gene encoding p15 INK4B has been mapped to chromosome 9p21.3 at a position adjacent to the p16 INK4A gene, at a site of frequent chromosomal abnormality in human tumors. Two p16 INK4A-related proteins, p19 INK4D and p18 INK4C, specifically inhibit the kinase activities of Cdk4 and Cdk6 but do not affect those of cyclin E-Cdk2, cyclin A-Cdk2 or cyclin B-Cdc2 complexes. p19 INK4D is expressed at maximal level during S phase, while overexpression of p19 INK4D leads to G1 arrest.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn