p-eEF2K Anticorpo F-8é um anticorpo monoclonal produzido em camundongo IgG1 (kappa light chain) fornecido em 200 µg/ml
recomendado para a detecção de Ser 366 phosphorylated eEF2K de mouse, rat e human origem em; Reage também com outras espécies, incluindo and equine, canine, bovine and porcine
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for p-eEF2K Antibody (F-8) for WB applications. These reagents are now offered in bundles with p-eEF2K Antibody (F-8) (see ordering information below).
ChemCruz™ Produtos químicos
eEF2K Inibidores para análise funcional de respostas celulares a eEF2K
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
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The activity of the purified eukaryotic elongation-factor-2 kinase (eEF2K) is completely dependent on calcium and calmodulin, and autophosphorylation on serine and threonine residues is calcium/calmodulin-dependent. eEF2K is a ubiquitous protein kinase that phosphorylates and inactivates eEF2, and thus can modulate the rate of polypeptide chain elongation during translation. eEF2K is detected in skeletal muscle extracts and is phosphorylated rapidly by SAPK4, but poorly by p38, p38g, JNK or ERK 2. SAPK4 phosphorylates eEF2K at Ser 359 and Ser 396 in vitro, causing its inactivation. The phosphorylation of eEF2K at Ser 359 is also induced by insulin-like growth factor-1. Ser 359 is in close proximity to Ser 366 and the Ser 366 residue also becomes phosphorylated in response to growth factors. eEF2K is phosphorylated by p70 S6 kinase at Ser 366 and this results in the inactivation of eEF2K, especially at low (micromolar) calcium concentrations.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.