NR2E1 Antibody (EE-9): sc-100905
- NR2E1 Antibody (EE-9) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant NR2E1 of human origin
- recommended for detection of NR2E1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NR2E1 Antibody (EE-9). This work is in progress.
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NR2E1 Antibody (EE-9) is a mouse monoclonal IgG2a antibody that detects NR2E1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). NR2E1, also known as TLX, plays a crucial role in the development of synaptic plasticity and the structural integrity of dendrites in retinal astrocytes, making NR2E1 vital for proper visual function and neural communication. NR2E1 is classified as an orphan nuclear receptor, which means NR2E1 binds to specific DNA sequences as part of the hormone response element, thereby regulating the transcription of target genes in response to hormonal signals. The DNA-binding domain of NR2E1 contains a conserved sequence motif, 5′-AAGGTCA-3′, which is essential for DNA interaction and determines substrate binding specificity. Predominantly expressed in brain tissue, NR2E1 is localized in the nucleus, where NR2E1 exerts regulatory functions. Importantly, mutations in the NR2E1 gene have been linked to retinal dystrophy, a condition that results in a thinning of the retina and can lead to significant visual impairment. Anti-NR2E1 antibody (EE-9) is an invaluable tool for researchers studying the molecular mechanisms underlying retinal development and associated disorders.
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NR2E1 Antibody (EE-9) References:
- Mutation and evolutionary analyses identify NR2E1-candidate-regulatory mutations in humans with severe cortical malformations. | Kumar, RA., et al. 2007. Genes Brain Behav. 6: 503-16. PMID: 17054721
- Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice. | Schmouth, JF., et al. 2012. Mol Cell Biol. 32: 1296-311. PMID: 22290436
- Modelling human regulatory variation in mouse: finding the function in genome-wide association studies and whole-genome sequencing. | Schmouth, JF., et al. 2012. PLoS Genet. 8: e1002544. PMID: 22396661
- The nuclear receptor NR2E1/TLX controls senescence. | O'Loghlen, A., et al. 2015. Oncogene. 34: 4069-4077. PMID: 25328137
- The Orphan Nuclear Receptor TLX/NR2E1 in Neural Stem Cells and Diseases. | Wang, T. and Xiong, JQ. 2016. Neurosci Bull. 32: 108-14. PMID: 26769490
- Co-activator candidate interactions for orphan nuclear receptor NR2E1. | Corso-Díaz, X., et al. 2016. BMC Genomics. 17: 832. PMID: 27782803
- Nuclear Receptor TLX in Development and Diseases. | Sun, G., et al. 2017. Curr Top Dev Biol. 125: 257-273. PMID: 28527574
- Genetic analysis of the NR2E1 gene as a candidate gene of schizophrenia. | Wang, YY., et al. 2020. Psychiatry Res. 293: 113386. PMID: 32805587
- Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration. | Zhu, X., et al. 2022. Cell Death Dis. 13: 785. PMID: 36096985
- A NR2E1-interacting peptide of LSD1 inhibits the proliferation of brain tumour initiating cells. | Hu, R., et al. 2023. Cell Prolif. 56: e13350. PMID: 36321378
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NR2E1 Antibody (EE-9) | sc-100905 | 100 µg/ml | $339.00 |