NALP2 Antibody (H-4) is an IgG1 κ mouse monoclonal NALP2 antibody (also designated NALP2 antibody) that detects the NALP2 protein of mouse, rat and human origin by WB, IP, IF and ELISA. NALP2 Antibody (H-4) is available as both the non-conjugated anti-NALP2 antibody form, as well as multiple conjugated forms of anti-NALP2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. NALP2 (PAN1, PYPAF2) is a 1,062 amino acid protein that catalyzes the suppression of TNF- and CD40-induced NFKB1 activity at the level of the IKK complex by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, NALP2 activates CASP1, which leads to the secretion of mature proinflammatory cytokine IL1B. As a putative member of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1, NALP2 may be involved in the activation of proinflammatory caspases. NALP2 shows predominant expression in lung, placenta and thymus tissues, and demonstrates lower levels of expression in ovary, intestine and brain tissues. NALP2 contains 1 DAPIN domain, 9 LRR (leucine-rich repeats) and 1 NACHT domain. The DAPIN domain is crucial for the suppression of NFKB1 activation and for inducing IL1B secretion in collaboration with caspase-1.
Alexa Fluor® é uma marca comercial da Molecular Probes Inc., OR., EUA
LI-COR® e Odyssey® são marcas registadas da LI-COR Biosciences
Informacoes sobre ordens
Nome do Produto | Numero de Catalogo | UNID | Preco | Qde | FAVORITOS | |
NALP2 Anticorpo (H-4) | sc-166584 | 200 µg/ml | $316.00 | |||
Pacote do NALP2 (H-4): m-IgG Fc BP-HRP | sc-527172 | 200 µg Ab; 10 µg BP | $354.00 | |||
Pacote do NALP2 (H-4): m-IgG1 BP-HRP | sc-532545 | 200 µg Ab; 20 µg BP | $354.00 | |||
NALP2 Anticorpo (H-4) AC | sc-166584 AC | 500 µg/ml, 25% agarose | $416.00 | |||
NALP2 Anticorpo (H-4) HRP | sc-166584 HRP | 200 µg/ml | $316.00 | |||
NALP2 Anticorpo (H-4) FITC | sc-166584 FITC | 200 µg/ml | $330.00 | |||
NALP2 Anticorpo (H-4) PE | sc-166584 PE | 200 µg/ml | $343.00 | |||
NALP2 Anticorpo (H-4) Alexa Fluor® 488 | sc-166584 AF488 | 200 µg/ml | $357.00 | |||
NALP2 Anticorpo (H-4) Alexa Fluor® 546 | sc-166584 AF546 | 200 µg/ml | $357.00 | |||
NALP2 Anticorpo (H-4) Alexa Fluor® 594 | sc-166584 AF594 | 200 µg/ml | $357.00 | |||
NALP2 Anticorpo (H-4) Alexa Fluor® 647 | sc-166584 AF647 | 200 µg/ml | $357.00 | |||
NALP2 Anticorpo (H-4) Alexa Fluor® 680 | sc-166584 AF680 | 200 µg/ml | $357.00 | |||
NALP2 Anticorpo (H-4) Alexa Fluor® 790 | sc-166584 AF790 | 200 µg/ml | $357.00 | |||
NALP2 (H-4) peptídeo neutralizante | sc-166584 P | 100 µg/0.5 ml | $68.00 |