MTMR2 Antibody (E-6): sc-271607
- MTMR2 Antibody (E-6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 47-77 near the N-terminus of MTMR2 of human origin
- recommended for detection of MTMR2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MTMR2 Antibody (E-6) for WB applications. These reagents are now offered in bundles with MTMR2 Antibody (E-6) (see ordering information below).
MTMR2 Antibody (E-6) is a mouse monoclonal IgG1 antibody that detects myotubularin 2 (MTMR2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MTMR2 plays a crucial role in cellular signaling and membrane dynamics by acting as a phosphatase that hydrolyzes inositol phospholipids, specifically Phosphatidylinositol 3-phosphate (PtdIns3P) and Phosphatidylinositol 4,5-bisphosphate (PtdInsP2). This enzymatic activity is vital for regulating various cellular processes, including endocytosis and autophagy, which are essential for maintaining cellular homeostasis and responding to stress. The importance of MTMR2 is underscored by involvement in the pathogenesis of autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), a genetic disorder characterized by peripheral nerve degeneration, highlighting MTMR2′s critical function in neuronal health. MTMR2 also interacts with other members of the myotubularin family, such as MTMR5, which enhances enzymatic activity and influences localization within the cell, further emphasizing the intricate regulatory networks involved. With broad species reactivity and versatility in various applications, anti-MTMR2 antibody (E-6) serves as an invaluable tool for researchers studying molecular mechanisms underlying myotubularin-related pathologies and cellular signaling pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTMR2 Antibody (E-6) | sc-271607 | 200 µg/ml | $322.00 | |||
MTMR2 Antibody (E-6): m-IgG Fc BP-HRP Bundle | sc-540252 | 200 µg Ab; 10 µg BP | $361.00 | |||
MTMR2 Antibody (E-6): m-IgG1 BP-HRP Bundle | sc-542001 | 200 µg Ab; 20 µg BP | $361.00 | |||
MTMR2 (E-6) Neutralizing Peptide | sc-271607 P | 100 µg/0.5 ml | $69.00 |