MCP-3 Antibody (G-2): sc-515890
- MCP-3 Antibody (G-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 43-99 mapping at the C-terminus of MCP-3 of human origin
- recommended for detection of MCP-3 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MCP-3 Antibody (G-2) for WB applications. These reagents are now offered in bundles with MCP-3 Antibody (G-2) (see ordering information below).
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MCP-3 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects MCP-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MCP-3, also known as chemokine (C-C motif) ligand 7, plays a crucial role in the immune response by mediating the migration and activation of various immune cells, including monocytes, dendritic cells, and lymphocytes. MCP-3 is primarily secreted by activated T lymphocytes and is essential for orchestrating inflammatory responses, particularly in conditions such as asthma and allergic reactions. The ability of MCP-3 to attract a diverse range of immune cells underscores its importance in both innate and adaptive immunity, making MCP-3 a key player in the body′s defense mechanisms. Additionally, MCP-3 is known to interact with specific receptors, such as CCR1 and CCR2, which are critical for its chemotactic functions. Anti-MCP-3 antibody (G-2) is an invaluable tool for researchers studying the dynamics of immune cell trafficking and the underlying mechanisms of various inflammatory diseases.
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MCP-3 Antibody (G-2) References:
- Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis. | Uguccioni, M., et al. 1999. Am J Pathol. 155: 331-6. PMID: 10433925
- Regulation of MCP-3 and BRCA2 mRNA expression levels by beta(1) integrins. | Moro, L., et al. 2001. Exp Mol Pathol. 70: 239-47. PMID: 11418002
- Gelatinase B, PECAM-1 and MCP-3 gene polymorphisms in Belgian multiple sclerosis. | Nelissen, I., et al. 2002. J Neurol Sci. 200: 43-8. PMID: 12127674
- MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission. | Modi, WS., et al. 2003. AIDS. 17: 2357-65. PMID: 14571188
- Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. | Tsou, CL., et al. 2007. J Clin Invest. 117: 902-9. PMID: 17364026
- Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP-dependent biogenesis pathway. | Sinzel, M., et al. 2016. EMBO Rep. 17: 965-81. PMID: 27226123
- Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta on human monocytes. | Uguccioni, M., et al. 1995. Eur J Immunol. 25: 64-8. PMID: 7531149
- Molecular cloning of the MCP-3 chemokine gene and regulation of its expression. | Minty, A., et al. 1993. Eur Cytokine Netw. 4: 99-110. PMID: 8318676
- RANTES and MCP-3 antagonists bind multiple chemokine receptors. | Gong, JH., et al. 1996. J Biol Chem. 271: 10521-7. PMID: 8631850
- Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. | Uguccioni, M., et al. 1996. J Exp Med. 183: 2379-84. PMID: 8642349
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCP-3 Antibody (G-2) | sc-515890 | 200 µg/ml | $322.00 | |||
MCP-3 Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-541090 | 200 µg Ab; 10 µg BP | $361.00 | |||
MCP-3 Antibody (G-2): m-IgG1 BP-HRP Bundle | sc-542573 | 200 µg Ab; 20 µg BP | $361.00 |