MAD1 Anticorpo (C-5): sc-137025
- MAD1 Anticorpo C-5é um anticorpo monoclonal produzido em camundongo IgG1 κ, citado em 5 publicações, fornecido em 200 µg/ml
- suscitadas contra os aminoácidos 241-540 que se mapeiam numa região interna de MAD1 de origem mouse
- recomendado para a detecção de MAD1 de mouse, rat e human origem em
- m-IgG Fc BP-HRP e 1 BP-HRP">m-IgG1 BP-HRP são os reagentes de deteção secundários preferidos para MAD1 Antibody (C-5) for WB applications. Estes reagentes são agora oferecidos em conjuntos com MAD1 Antibody (C-5)(ver informações de encomenda abaixo).
LINKS RÁPIDOS
Cell cycle progression is subject to arrest at the mitotic spindle assembly checkpoint in response to incorrect spindle fiber assembly. MAD1 and MAD2 (for mitotic arrest-deficient 1 and 2) are components of the mitotic spindle checkpoint. Incorrect spindle assembly in normal cells leads to mitotic arrest. MAD1 prevents the onset of anaphase until all chromosomes are aligned correctly at the metaphase plate and is crucial for anchoring MAD2L1 to the nuclear periphery. It also plays an important role in septum positioning. MAD1 can form a homo-dimer, but may also form a heterodimer with MAD2 to form the tetrameric MAD1L1-MAD2L1 core complex. MAD1 localizes primarily to the nucleus, but during mitosis, it moves from a nuclear distribution to the centrosome, to the spindle midzone and then on to the midbody. MAD1 activity is induced by BUB1 and the protein is hyperphosphorylated after mitotic spindle damage and/or in late S through M phase. Defects in the gene encoding for MAD1, MAD1L1, play a major role in the development and progression of various cancer types.
Informacoes sobre ordens
| Nome do Produto | Numero de Catalogo | UNID | Preco | Qde | FAVORITOS | |
MAD1 Anticorpo (C-5) | sc-137025 | 200 µg/ml | $316.00 | |||
Pacote do MAD1 (C-5): m-IgG Fc BP-HRP | sc-539919 | 200 µg Ab; 10 µg BP | $354.00 | |||
Pacote do MAD1 (C-5): m-IgG1 BP-HRP | sc-541787 | 200 µg Ab; 20 µg BP | $354.00 |