IL-8RB Antibody (E-2): sc-7304

IL-8RB Antibody (E-2) is a mouse monoclonal IgG_2a antibody that detects the IL-8RB protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). IL-8RB monoclonal antibody (E-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The IL-8RB protein, also known as C-X-C motif chemokine receptor 2, plays a crucial role in mediating inflammatory responses by acting as a receptor for interleukin-8 (IL-8), a potent chemotactic factor for neutrophils. This receptor is predominantly expressed on neutrophils, with lower levels found on monocytes and certain myeloid cell lines, which underscores its importance in the immune response and inflammation. Notably, IL-8RB is part of the seven transmembrane domain rhodopsin superfamily of receptors, which are essential for G protein-coupled signal transduction. The interaction of IL-8RB with IL-8 not only facilitates neutrophil chemotaxis but also enhances their activation, making IL-8RB a key player in the pathophysiology of various inflammatory diseases. Understanding the dynamics of IL-8RB and its signaling pathways can provide insights into therapeutic targets for conditions characterized by excessive inflammation.

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IL-8RB Antibody (E-2) References:

1. Human cytokine gene nucleotide sequence alignments: interleukin 4 receptor alpha chain (IL4RA), IL5RA, IL8, IL8RB and IL13.  |  Laundy, GJ. and Bidwell, JL. 2003. Eur J Immunogenet. 30: 13-87. PMID: 12558816
2. Interleukin-8 as a macrophage-derived mediator of angiogenesis.  |  Koch, AE., et al. 1992. Science. 258: 1798-801. PMID: 1281554
3. Characterization of two high affinity human interleukin-8 receptors.  |  Lee, J., et al. 1992. J Biol Chem. 267: 16283-7. PMID: 1379593
4. G-protein activation by interleukin 8 and related cytokines in human neutrophil plasma membranes.  |  Kupper, RW., et al. 1992. Biochem J. 282 (Pt 2): 429-34. PMID: 1546956
5. Structure and functional expression of a human interleukin-8 receptor.  |  Holmes, WE., et al. 1991. Science. 253: 1278-80. PMID: 1840701
6. Cloning of complementary DNA encoding a functional human interleukin-8 receptor.  |  Murphy, PM. and Tiffany, HL. 1991. Science. 253: 1280-3. PMID: 1891716
7. Blockage of C-X-C Motif Chemokine Receptor 2 (CXCR2) Suppressed Uric Acid (UA)-Induced Cardiac Remodeling.  |  Xu, M., et al. 2021. Front Physiol. 12: 700338. PMID: 34385934
8. Prevention of Chemotherapy-Induced Peripheral Neuropathy by Inhibiting C-X-C Motif Chemokine Receptor 2.  |  Cho, HS., et al. 2023. Int J Mol Sci. 24: PMID: 36768178
9. Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes.  |  Chuntharapai, A., et al. 1994. J Immunol. 153: 5682-8. PMID: 7527448
10. Interleukin-8: a review.  |  Hébert, CA. and Baker, JB. 1993. Cancer Invest. 11: 743-50. PMID: 8221207
11. Characterization of interleukin-8 receptors in human neutrophil membranes: regulation by guanine nucleotides.  |  Barnett, ML., et al. 1993. Biochim Biophys Acta. 1177: 275-82. PMID: 8323978
12. Expression of transcripts for two interleukin 8 receptors in human phagocytes, lymphocytes and melanoma cells.  |  Moser, B., et al. 1993. Biochem J. 294 (Pt 1): 285-92. PMID: 8363581

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-8RB Antibody (E-2) has 29 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-8RB Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-8RB Antibody (E-2) Specifications

Alternate Product Name: CXCR2

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a lambda light chain

Amino Acids: 1-19

Epitope Target: IL-8RB

Epitope Species: human

Product Reactivity/Detection: IL-8RB

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG_2a lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 29 citations in various scientific publications

Available Conjugates/Forms for IL-8RB Antibody (E-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin