GSK3 beta Antibody (1F7): sc-53931

GSK-3β Antibody (1F7) is a mouse monoclonal IgG1 that specifically targets glycogen synthase kinase 3 beta (GSK-3β), detecting the protein in mouse, rat, and human samples via western blotting (WB) and immunoprecipitation (IP). GSK-3β, also referred to as GSK3, GSK-3, and GSK-3beta, is a serine/threonine kinase involved in numerous critical signaling pathways, including those regulating glycogen metabolism, cell differentiation, and cellular adhesion. GSK-3β (1F7) antibody helps researchers study how GSK-3β phosphorylates target proteins, thereby influencing a variety of cellular processes. One of GSK-3β′s most significant roles is in glycogen synthesis, where GSK-3β phosphorylates and inhibits glycogen synthase, the enzyme responsible for converting glucose to glycogen, thus regulating energy storage. Aberrations in GSK-3β activity have been linked to several pathological conditions, including neurodegenerative diseases such as Alzheimer′s, where GSK-3β hyperphosphorylates the microtubule-associated protein Tau. This excessive phosphorylation contributes to the formation of paired helical filaments (PHFs), which are the primary components of neurofibrillary tangles observed in Alzheimer′s disease. By studying GSK-3β with anti-GSK-3β antibody (1F7), researchers can gain insight into its diverse roles in cellular function and potential contribution to disease mechanisms, making this tool valuable for investigations into cellular signaling and metabolic regulation.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GSK3 beta Antibody (1F7) has 33 citations in a variety of scientific publications.

Primary antibodies like Anti-GSK3 beta Antibody (1F7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GSK3 beta Antibody (1F7) Specifications

Alternate Product Name: GSK3

Product Clone Name: 1F7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 341-420

Epitope Target: GSK-3β

Epitope Species: human

Product Reactivity/Detection: GSK-3β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 1% glycerol

Research Citations: 33 citations in various scientific publications

Available Conjugates/Forms for GSK3 beta Antibody (1F7): N/A

The preferred GSK3 alpha/beta antibody is GSK3 alpha/beta Antibody (0011-A): sc-7291.