Fibromodulin Antibody (E-12): sc-166498
- Fibromodulin Antibody (E-12) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 46-59 near the N-terminus of Fibromodulin of human origin
- recommended for detection of Fibromodulin of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Fibromodulin Antibody (E-12). This work is in progress.
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Fibromodulin Antibody (E-12) is a mouse monoclonal IgG1 antibody that detects Fibromodulin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fibromodulin is a crucial component of the extracellular matrix, primarily found in articular cartilage, tendon, and ligament, where anti-Fibromodulin antibody (E-12) plays a significant role in collagen fibril organization and stability. Fibromodulin regulates the spacing and thickness of collagen fibrils, which is vital for proper tissue function and mechanical properties. The core structure of Fibromodulin consists of a central region rich in leucine repeats, flanked by terminal domains that form disulfide linkages, contributing to stability and functionality. The human Fibromodulin gene is located on chromosome 1q32 and encodes a 376 amino acid protein, highlighting evolutionary conservation and importance in various biological processes. Fibromodulin monoclonal antibody (E-12) serves as an invaluable tool for researchers studying connective tissue disorders, fibrosis, and other related conditions, providing insights into molecular mechanisms underlying extracellular matrix dynamics.
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Fibromodulin Antibody (E-12) References:
- Fibromodulin deficiency reduces low-density lipoprotein accumulation in atherosclerotic plaques in apolipoprotein E-null mice. | Shami, A., et al. 2013. Arterioscler Thromb Vasc Biol. 33: 354-61. PMID: 23202368
- Fibromodulin promoted in vitro and in vivo angiogenesis. | Jian, J., et al. 2013. Biochem Biophys Res Commun. 436: 530-535. PMID: 23770359
- Absence of fibromodulin affects matrix composition, collagen deposition and cell turnover in healthy and fibrotic lung parenchyma. | Rydell-Törmänen, K., et al. 2014. Sci Rep. 4: 6383. PMID: 25230586
- Fibromodulin Expression in Folliculostellate Cells and Pericytes Is Promoted by TGFβ Signaling in Rat Anterior Pituitary Gland. | Syaidah, R., et al. 2016. Acta Histochem Cytochem. 49: 171-179. PMID: 28127105
- Fibromodulin and regulation of the intricate balance between myoblast differentiation to myocytes or adipocyte-like cells. | Lee, EJ., et al. 2018. FASEB J. 32: 768-781. PMID: 28974563
- Fibromodulin reduces scar size and increases scar tensile strength in normal and excessive-mechanical-loading porcine cutaneous wounds. | Jiang, W., et al. 2018. J Cell Mol Med. 22: 2510-2513. PMID: 29392829
- CDKN2B upregulation prevents teratoma formation in multipotent fibromodulin-reprogrammed cells. | Zheng, Z., et al. 2019. J Clin Invest. 129: 3236-3251. PMID: 31305260
- The Association of Cell Surface Fibromodulin Expression and Bladder Carcinoma. | Bayat, AA., et al. 2021. Urol J. 19: 189-195. PMID: 34247360
- Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth. | Sengupta, S., et al. 2022. Elife. 11: PMID: 35642785
- Differential MMP-14 targeting by biglycan, decorin, fibromodulin, and lumican unraveled by in silico approach. | Rivet, R., et al. 2023. Am J Physiol Cell Physiol. 324: C353-C365. PMID: 36534501
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fibromodulin Antibody (E-12) | sc-166498 | 200 µg/ml | $322.00 | |||
Fibromodulin (E-12) Neutralizing Peptide | sc-166498 P | 100 µg/0.5 ml | $69.00 |