FANCM Antibody (M40-P2C6): sc-101389

FANCM Antibody (M40-P2C6) is a mouse monoclonal IgG1 kappa light chain antibody that detects FANCM protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-FANCM antibody (M40-P2C6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FANCM, or Fanconi anemia, complementation group M, plays a crucial role in maintaining genomic stability, as part of the Fanconi anemia (FA) pathway, which is essential for repairing DNA interstrand cross-links. This pathway is vital for cellular response to DNA damage, and defects in FANCM can lead to the development of Fanconi anemia, a genetic disorder characterized by bone marrow failure, developmental abnormalities, and increased cancer risk. FANCM protein is localized to chromatin fractions and undergoes phosphorylation in a cell cycle-dependent manner, which is important for recruiting the FA core complex to sites of DNA damage. This recruitment is critical for the monoubiquitination of FANCD2, a key step in the DNA repair process. Understanding the function and interactions of FANCM is essential for elucidating the mechanisms underlying genomic stability and the pathogenesis of Fanconi anemia, making FANCM (M40-P2C6) monoclonal antibody a valuable tool for researchers studying these processes.

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FANCM Antibody (M40-P2C6) References:

1. The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG.  |  de Winter, JP., et al. 2000. Hum Mol Genet. 9: 2665-74. PMID: 11063725
2. A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA.  |  Yagasaki, H., et al. 2001. Blood. 98: 3650-7. PMID: 11739169
3. Function of the Fanconi anemia pathway in Fanconi anemia complementation group F and D1 cells.  |  Siddique, MA., et al. 2001. Exp Hematol. 29: 1448-55. PMID: 11750104
4. The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange.  |  Wilson, JB., et al. 2001. Carcinogenesis. 22: 1939-46. PMID: 11751423
5. Phosphorylation of Fanconi anemia protein, FANCA, is regulated by Akt kinase.  |  Otsuki, T., et al. 2002. Biochem Biophys Res Commun. 291: 628-34. PMID: 11855836
6. Molecular pathogenesis of fanconi anemia.  |  Taniguchi, T. and Dandrea, AD. 2002. Int J Hematol. 75: 123-8. PMID: 11939257
7. Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma.  |  Wreesmann, VB., et al. 2007. ORL J Otorhinolaryngol Relat Spec. 69: 218-25. PMID: 17409780
8. Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24.  |  Kim, JM., et al. 2008. Blood. 111: 5215-22. PMID: 18174376
9. ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres.  |  O'Rourke, JJ., et al. 2019. Nucleus. 10: 221-230. PMID: 31663812
10. FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women.  |  Figlioli, G., et al. 2023. Eur J Hum Genet. 31: 578-587. PMID: 36707629
11. Spectrum and Frequency of Germline FANCM Protein-Truncating Variants in 44,803 European Female Breast Cancer Cases.  |  Figlioli, G., et al. 2023. Cancers (Basel). 15: PMID: 37444426
12. FANCM branchpoint translocase: Master of traverse, reverse and adverse DNA repair.  |  Abbouche, L., et al. 2024. DNA Repair (Amst). 140: 103701. PMID: 38878565

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FANCM Antibody (M40-P2C6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-FANCM Antibody (M40-P2C6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FANCM Antibody (M40-P2C6) Specifications

Alternate Product Name: FANCM

Product Clone Name: M40-P2C6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2034-2043

Epitope Target: FANCM

Epitope Species: human

Product Reactivity/Detection: FANCM

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for FANCM Antibody (M40-P2C6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin