emerin Antibody (H-7): sc-393247
- emerin Antibody (H-7) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 195-224 near the C-terminus of emerin of mouse origin
- Anti-emerin Antibody (H-7) is recommended for detection of emerin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-emerin Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for emerin Antibody (H-7) for WB and IHC(P) applications. These reagents are now offered in bundles with emerin Antibody (H-7) (see ordering information below).
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SEE ALSO...
emerin Antibody (H-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects emerin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-emerin antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. emerin plays a crucial role in maintaining the structural integrity of the nuclear envelope, as emerin is a key component of the nuclear lamina, which provides mechanical support to the nucleus. This structural function is vital for proper cellular organization and gene expression regulation. Notably, mutations in the gene encoding emerin lead to Emery-Dreyfuss muscular dystrophy (EDMD), a condition characterized by progressive muscle weakness and cardiac issues, highlighting emerin′s importance in muscle and heart function. emerin′s localization to desmosomes and fasciae adherentes in cardiac tissue is particularly significant, as this may contribute to conduction defects observed in EDMD patients, underscoring emerin′s essential role in both muscle and cardiac health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
emerin Antibody (H-7) References:
- Both emerin and lamin C depend on lamin A for localization at the nuclear envelope. | Vaughan, A., et al. 2001. J Cell Sci. 114: 2577-90. PMID: 11683386
- Emerin organizes actin flow for nuclear movement and centrosome orientation in migrating fibroblasts. | Chang, W., et al. 2013. Mol Biol Cell. 24: 3869-80. PMID: 24152738
- Emerin expression in well differentiated epithelial lesions of thyroid: implications in papillary thyroid carcinoma diagnosis and predicting malignant behavior. | Coban, I., et al. 2015. Pathol Oncol Res. 21: 357-66. PMID: 25116851
- Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient. | Shimojima, M., et al. 2017. Sci Rep. 7: 44312. PMID: 28290476
- Emerin anchors Msx1 and its protein partners at the nuclear periphery to inhibit myogenesis. | Ma, Z., et al. 2019. Cell Biosci. 9: 34. PMID: 31044068
- Probing the Environment of Emerin by Enhanced Ascorbate Peroxidase 2 (APEX2)-Mediated Proximity Labeling. | Müller, M., et al. 2020. Cells. 9: PMID: 32138363
- Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization. | Cenni, V., et al. 2020. Cells. 9: PMID: 32517247
- BCAP31 is involved in modulating colorectal cancer cell proliferation via the Emerin/β-catenin axis. | Han, L., et al. 2022. Exp Cell Res. 418: 113265. PMID: 35716785
- Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis. | Xie, Y., et al. 2024. bioRxiv.. PMID: 38979362
- The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein. | Manilal, S., et al. 1996. Hum Mol Genet. 5: 801-8. PMID: 8776595
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
emerin Antibody (H-7) | sc-393247 | 200 µg/ml | $322.00 | |||
emerin Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-526232 | 200 µg Ab; 10 µg BP | $361.00 | |||
emerin Antibody (H-7): m-IgG2a BP-HRP Bundle | sc-546534 | 200 µg Ab; 10 µg BP | $361.00 | |||
emerin Antibody (H-7) AC | sc-393247 AC | 500 µg/ml, 25% agarose | $424.00 | |||
emerin Antibody (H-7) HRP | sc-393247 HRP | 200 µg/ml | $322.00 | |||
emerin Antibody (H-7) FITC | sc-393247 FITC | 200 µg/ml | $336.00 | |||
emerin Antibody (H-7) PE | sc-393247 PE | 200 µg/ml | $349.00 | |||
emerin Antibody (H-7) Alexa Fluor® 488 | sc-393247 AF488 | 200 µg/ml | $364.00 | |||
emerin Antibody (H-7) Alexa Fluor® 546 | sc-393247 AF546 | 200 µg/ml | $364.00 | |||
emerin Antibody (H-7) Alexa Fluor® 594 | sc-393247 AF594 | 200 µg/ml | $364.00 | |||
emerin Antibody (H-7) Alexa Fluor® 647 | sc-393247 AF647 | 200 µg/ml | $364.00 | |||
emerin Antibody (H-7) Alexa Fluor® 680 | sc-393247 AF680 | 200 µg/ml | $364.00 | |||
emerin Antibody (H-7) Alexa Fluor® 790 | sc-393247 AF790 | 200 µg/ml | $364.00 | |||
emerin (H-7) Neutralizing Peptide | sc-393247 P | 100 µg/0.5 ml | $69.00 |