Date published: 2026-4-24

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D-Propargylglycine (CAS 23235-03-2)

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Application:
D-Propargylglycine is a useful biochemical for proteomics research
CAS Number:
23235-03-2
Molecular Weight:
113.10
Molecular Formula:
C5H7NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-Propargylglycine (D-PPG) is an organosulfur compound useful for proteomics research. It is a synthetic molecule that can be used as a catalyst in organic synthesis, a substrate for enzyme studies, a ligand in coordination chemistry, and a pharmacological agent for studying biochemical and physiological processes. This compound acts as an inhibitor of the enzyme transglutaminase, which is involved in the formation of cross-links between proteins. In addition, D-Propargylglycine inhibits the activity of several other enzymes, including cyclooxygenase, lipoxygenase, and phospholipase A2, which are involved in the formation of inflammatory mediators and the regulation of cell signaling pathways. It has also been shown to modulate the activity of various transcription factors and to affect the expression of genes involved in cell proliferation, differentiation, and apoptosis. D-Propargylglycine has anti-inflammatory, antioxidant, and anti-apoptotic effects.


D-Propargylglycine (CAS 23235-03-2) References

  1. Development and Characterization of Potent Peptide Inhibitors of p60c-src PTK Using Pseudosubstrate-Based Inhibitor Design Approach  |  , et al. Peptides: The Wave of the Future. volume 7): pp 551–552.
  2. Nephrotoxicity of D-proparglyglycine in mice.  |  Konno, R., et al. 2000. Arch Toxicol. 74: 473-9. PMID: 11097385
  3. D-amino-acid oxidase is involved in D-serine-induced nephrotoxicity.  |  Maekawa, M., et al. 2005. Chem Res Toxicol. 18: 1678-82. PMID: 16300376
  4. Irreversible inactivation of snake venom l-amino acid oxidase by covalent modification during catalysis of l-propargylglycine.  |  Mitra, J. and Bhattacharyya, D. 2013. FEBS Open Bio. 3: 135-43. PMID: 23772385
  5. Phenylalanine Ammonia-Lyase-Catalyzed Deamination of an Acyclic Amino Acid: Enzyme Mechanistic Studies Aided by a Novel Microreactor Filled with Magnetic Nanoparticles.  |  Weiser, D., et al. 2015. Chembiochem. 16: 2283-8. PMID: 26345352
  6. Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables In Vivo Imaging of Gut Microbiota.  |  Wang, W., et al. 2020. Angew Chem Int Ed Engl. 59: 2628-2633. PMID: 31793153
  7. Sequence of reactions which follows enzymatic oxidation of propargylglycine.  |  Marcotte, P. and Walsh, C. 1978. Biochemistry. 17: 5613-9. PMID: 31908
  8. Metabolic Labeling Strategy Boosted Antibacterial Efficiency for Photothermal and Photodynamic Synergistic Bacteria-Infected Wound Therapy.  |  Li, N., et al. 2022. ACS Appl Mater Interfaces. 14: 46362-46373. PMID: 36198018
  9. Affinity labeling of D-amino acid oxidase with an acetylenic substrate.  |  Horiike, K., et al. 1975. J Biochem. 78: 57-63. PMID: 379
  10. Suicide inactivation of bacterial cystathionine gamma-synthase and methionine gamma-lyase during processing of L-propargylglycine.  |  Johnston, M., et al. 1979. Biochemistry. 18: 4690-701. PMID: 387077
  11. Studies on the reaction of D-amino acid oxidase with beta-cyano-D-alanine. Observation of an intermediary stable charge transfer complex.  |  Miura, R., et al. 1980. J Biochem. 87: 1469-81. PMID: 6104660
  12. Vinylglycine and proparglyglycine: complementary suicide substrates for L-amino acid oxidase and D-amino acid oxidase.  |  Marcotte, P. and Walsh, C. 1976. Biochemistry. 15: 3070-6. PMID: 8082
  13. Synthesis of the suicide substrate D-propargylglycine stereospecifically labelled with deuterium and investigation of its oxidation by D-amino acid oxidase[hair space]1  |  Nicola J. Church and Douglas W. Young. 1998. J. Chem. Soc., Perkin Trans. 1,,: 1475-1482.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-Propargylglycine, 1 g

sc-285386
1 g
$265.00

D-Propargylglycine, 5 g

sc-285386A
5 g
$867.00