Cyclosporin A Antibody (H4 1.3): sc-69888
- Cyclosporin A Antibody (H4 1.3) is a mouse monoclonal IgG1 κ Cyclosporin A antibody provided at 200 µg/ml
- raised against BSA-conjugated Cyclosporine A, a cyclic undecapeptide of fungal origin
- Cyclosporin A Antibody (H4 1.3) is recommended for detection of Cyclosporine A of fungal origin by ELISA
- Anti-Cyclosporin A Antibody (H4 1.3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also provided azide-free for inhibition assays, sc-69888 L,
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Cyclosporin A Antibody (H4 1.3). These reagents are now offered in bundles with Cyclosporin A Antibody (H4 1.3) (see ordering information below).
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Cyclosporin A Antibody (H4 1.3) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cyclosporin A protein of fungal origin by enzyme-linked immunosorbent assay (ELISA). Anti-Cyclosporin A antibody (H4 1.3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Cyclosporin A, also known as CsA, is a potent immunosuppressive compound derived from the fungus Tolypocladium inflatum, and its discovery in 1971 revolutionized immunopharmacology. Cyclosporin A selectively inhibits T cell activation by blocking calcineurin activity, which prevents interleukin-2 (IL-2) transcription, a critical cytokine for T cell proliferation and function. This mechanism reduces organ rejection risk in transplant surgeries and highlights targeted immunoregulation importance in therapeutic applications. Cyclosporin A′s role in inhibiting permeability-transition pores in mitochondria underscores potential neuroprotective properties, offering promise in mitigating damage from head trauma and neurodegenerative diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cyclosporin A Antibody (H4 1.3) References:
- Cyclosporine and long-term kidney graft survival. | Opelz, G. and Döhler, B. 2001. Transplantation. 72: 1267-73. PMID: 11602854
- Cyclosporin A and FK506 inhibit IL-12p40 production through the calmodulin/calmodulin-dependent protein kinase-activated phosphoinositide 3-kinase in lipopolysaccharide-stimulated human monocytic cells. | Ma, W., et al. 2007. J Biol Chem. 282: 13351-62. PMID: 17347151
- Hepatotoxicity caused by both tacrolimus and cyclosporine after living donor liver transplantation. | Taniai, N., et al. 2008. J Nippon Med Sch. 75: 187-91. PMID: 18648179
- Comparative permeability and diffusion kinetics of cyclosporine A liposomes and propylene glycol solution from human lung tissue into human blood ex vivo. | Trammer, B., et al. 2008. Eur J Pharm Biopharm. 70: 758-64. PMID: 18656538
- Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A. | Ko, H., et al. 2008. Transpl Immunol. 20: 99-105. PMID: 18662782
- Evaluation of topical ciclosporin 0.05% for prevention of rejection in high-risk corneal grafts. | Unal, M. and Yücel, I. 2008. Br J Ophthalmol. 92: 1411-4. PMID: 18662913
- In vitro effect of cyclosporin A on primary and chronic BK polyoma virus infection in Vero E6 cells. | Acott, PD., et al. 2008. Transpl Infect Dis. 10: 385-90. PMID: 18665906
- Effect of cyclosporine on reperfusion injury in acute myocardial infarction. | Piot, C., et al. 2008. N Engl J Med. 359: 473-81. PMID: 18669426
- Cyclosporin A pre-incubation attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells. | Chen, TL., et al. 2008. Scand J Clin Lab Invest. 68: 585-93. PMID: 19378430
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyclosporin A Antibody (H4 1.3) | sc-69888 | 200 µg/ml | $322.00 | |||
Cyclosporin A Antibody (H4 1.3): m-IgG Fc BP-HRP Bundle | sc-526994 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cyclosporin A Antibody (H4 1.3): m-IgG1 BP-HRP Bundle | sc-532367 | 200 µg Ab; 20 µg BP | $361.00 | |||
Cyclosporin A Antibody (H4 1.3) AC | sc-69888 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Cyclosporin A Antibody (H4 1.3) HRP | sc-69888 HRP | 200 µg/ml | $322.00 | |||
Cyclosporin A Antibody (H4 1.3) FITC | sc-69888 FITC | 200 µg/ml | $336.00 | |||
Cyclosporin A Antibody (H4 1.3) PE | sc-69888 PE | 200 µg/ml | $349.00 | |||
Cyclosporin A Antibody (H4 1.3) Alexa Fluor® 488 | sc-69888 AF488 | 200 µg/ml | $364.00 | |||
Cyclosporin A Antibody (H4 1.3) Alexa Fluor® 546 | sc-69888 AF546 | 200 µg/ml | $364.00 | |||
Cyclosporin A Antibody (H4 1.3) Alexa Fluor® 594 | sc-69888 AF594 | 200 µg/ml | $364.00 | |||
Cyclosporin A Antibody (H4 1.3) Alexa Fluor® 647 | sc-69888 AF647 | 200 µg/ml | $364.00 | |||
Cyclosporin A Antibody (H4 1.3) Alexa Fluor® 680 | sc-69888 AF680 | 200 µg/ml | $364.00 | |||
Cyclosporin A Antibody (H4 1.3) Alexa Fluor® 790 | sc-69888 AF790 | 200 µg/ml | $364.00 |