cyclin B1 Anticorpo 0.N.238é um anticorpo monoclonal produzido em camundongo IgG1 κ, citado em 14 publicações, fornecido em 200 µg/ml
raised against a recombinant protein corresponding to human cyclin B1
recomendado para a detecção de cyclin B1 de mouse, rat e human origem em
See cyclin B1 (GNS1): sc-245 for additional antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for cyclin B1 Antibody (0.N.238) for WB and IHC(P) applications. This reagent is now offered in a bundle with cyclin B1 Antibody (0.N.238) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
ChemCruz™ Produtos químicos
cyclin B1 Inibidores para análise funcional de respostas celulares a Cyclin
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In eukaryotic cells, mitosis is initiated following the activation of a protein kinase known variously as maturation-promoting factor, M-phase specific histone kinase or M-phase kinase. This protein kinase is composed of a catalytic subunit (Cdc2), a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc 1). The Cdc/cyclin enzyme is subject to multiple levels of control, of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/cyclin B enzyme; tyrosine dephosphorylation, occurring at the onset of mitosis, directly activates the pre-MPF complex. Evidence has established that B type cyclins not only act on M-phase regulatory subunits of the Cdc2 protein kinase, but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase, of which Cdc2 is the physiological substrate. The specificity of this effect is shown by the inability of either cyclin A or cyclin D1 to display any such stimulation of Cdc25A or Cdc25B.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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