Cortisol Antibody (CORT-1): sc-51840

Cortisol Antibody (CORT-1) is a mouse monoclonal IgG1 antibody that detects Cortisol of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-Cortisol antibody (CORT-1) is available as a non-conjugated format, providing researchers with a reliable tool for studying this critical hormone. Cortisol, the most potent glucocorticoid produced by the human adrenal cortex, plays a vital role in the body′s response to stress. Cortisol is synthesized from cholesterol, with production stimulated by pituitary adrenocorticotropic hormone (ACTH), which is regulated by corticotropin-releasing factor (CRF). The intricate balance of these hormones is essential for maintaining homeostasis, as high Cortisol levels trigger a negative feedback loop that inhibits ACTH and CRF secretion. In the bloodstream, most Cortisol binds with high affinity to corticosteroid binding globulin (CBG), also known as transcortin, which helps regulate bioavailability. Cortisol acts through specific intracellular receptors, influencing various physiological processes, including blood pressure and blood sugar modulation, while suppressing immune responses. Understanding Cortisol dynamics and interactions is crucial for elucidating stress response and related disorders, making Cortisol monoclonal antibody (CORT-1) an invaluable research tool.

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Cortisol Antibody (CORT-1) References:

1. Cortisol circadian rhythms during the menstrual cycle and with sleep deprivation in premenstrual dysphoric disorder and normal control subjects.  |  Parry, BL., et al. 2000. Biol Psychiatry. 48: 920-31. PMID: 11074230
2. Gender differences in the urinary excretion rates of cortisol and androgen metabolites.  |  Shamim, W., et al. 2000. Ann Clin Biochem. 37 (Pt 6): 770-4. PMID: 11085621
3. Effects of rapid tryptophan depletion on salivary and plasma cortisol in Alzheimer's disease and the healthy elderly.  |  Porter, RJ., et al. 2002. J Psychopharmacol. 16: 73-8. PMID: 11949775
4. Relationship between changes in mRNAs of the genes encoding steroidogenic acute regulatory protein and P450 cholesterol side chain cleavage in head kidney and plasma levels of cortisol in response to different kinds of acute stress in the rainbow trout (Oncorhynchus mykiss).  |  Geslin, M. and Auperin, B. 2004. Gen Comp Endocrinol. 135: 70-80. PMID: 14644646
5. Long-term predictive value of postsurgical cortisol concentrations for cure and risk of recurrence in Cushing's disease.  |  Pereira, AM., et al. 2003. J Clin Endocrinol Metab. 88: 5858-64. PMID: 14671181
6. No major effect of orciprenaline and propranolol upon ACTH-induced cortisol secretion.  |  Nonell, A., et al. 2004. Exp Clin Endocrinol Diabetes. 112: 59-61. PMID: 14758573
7. Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia.  |  Hatfield, CF., et al. 2004. Brain. 127: 1061-74. PMID: 14998915
8. Cortisol metabolism in hypertension.  |  Hammer, F. and Stewart, PM. 2006. Best Pract Res Clin Endocrinol Metab. 20: 337-53. PMID: 16980198
9. Interpretation of the short Synacthen test in the presence of low cortisol-binding globulin: two case reports.  |  Moisey, R., et al. 2006. Ann Clin Biochem. 43: 416-9. PMID: 17022886

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cortisol Antibody (CORT-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Cortisol Antibody (CORT-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cortisol Antibody (CORT-1) Specifications

Alternate Product Name: Cortisol

Product Clone Name: CORT-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Cortisol

Epitope Species: human

Product Reactivity/Detection: Cortisol

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Cortisol Antibody (CORT-1): N/A