CD84 Antibody (E-3): sc-398321

CD84 Antibody (E-3) is a mouse monoclonal IgG1 antibody that detects CD84 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD84 is a member of the immunoglobulin superfamily and plays a crucial role in immune responses, particularly in the activation and regulation of B lymphocytes, monocytes, and platelets. CD84 is primarily located on the surface of these immune cells, where CD84 functions as a costimulatory molecule, enhancing the activation signals necessary for effective immune responses. Notably, CD84 exists in five isoforms—CD84a, CD84b, CD84c, CD84d, and CD84e—each exhibiting distinct expression patterns and regulatory mechanisms. The presence of various phosphorylation sites across these isoforms suggests a sophisticated level of regulation that can modulate CD84′s activity during signal transduction, thereby influencing immune cell behavior. CD84′s ability to act as its own ligand further underscores CD84′s importance in facilitating intercellular communication and promoting immune system functionality. With versatile applications and critical role in immune regulation, anti-CD84 antibody (E-3) serves as an essential tool for researchers studying immune responses and related pathways.

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CD84 Antibody (E-3) References:

1. CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1.  |  Martin, M., et al. 2001. J Immunol. 167: 3668-76. PMID: 11564780
2. CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2.  |  Tangye, SG., et al. 2002. Eur J Immunol. 32: 1640-9. PMID: 12115647
3. CD84 expression on human hematopoietic progenitor cells.  |  Zaiss, M., et al. 2003. Exp Hematol. 31: 798-805. PMID: 12962726
4. CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells.  |  Álvarez-Errico, D., et al. 2011. J Immunol. 187: 5577-86. PMID: 22068234
5. The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets.  |  Hofmann, S., et al. 2012. J Thromb Haemost. 10: 2581-92. PMID: 23025437
6. CD84 is markedly up-regulated in Kawasaki disease arteriopathy.  |  Reindel, R., et al. 2014. Clin Exp Immunol. 177: 203-11. PMID: 24635044
7. CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia.  |  Lewinsky, H., et al. 2018. J Clin Invest. 128: 5465-5478. PMID: 30277471
8. CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke.  |  Schuhmann, MK., et al. 2020. Circ Res. 127: 1023-1035. PMID: 32762491
9. CCL2 mediated IKZF1 expression promotes M2 polarization of glioma-associated macrophages through CD84-SHP2 pathway.  |  Song, Y., et al. 2024. Oncogene. 43: 2737-2749. PMID: 39112517
10. Targeting CD84 protein on myeloid-derived suppressor cells as a novel immunotherapy in solid tumors.  |  Mobini, S., et al. 2025. Comput Methods Programs Biomed. 261: 108607. PMID: 39847992

The preferred CD84 antibody is CD84 Antibody (152-1D5): sc-23899.