CD74 Antibody (OX4): sc-53061

CD74 Antibody (OX4) is a mouse monoclonal IgG1 antibody that detects CD74 in mouse and rat samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD74, also known as the invariant chain, plays a crucial role in the immune system by regulating the loading of peptides onto major histocompatibility complex class II (MHC II) molecules. This process is vital for the proper presentation of antigens to T lymphocytes, which is essential for initiating adaptive immune responses. CD74 is predominantly expressed in B lymphocytes and is also found in a subset of T lymphocytes, highlighting CD74′s importance in both humoral and cellular immunity. CD74 expression on immune cells not only facilitates the transport of MHC II to the endosomal compartment but also influences the activation and differentiation of T cells, making CD74 a key player in immune regulation. With a broad expression profile and critical function in antigen presentation, CD74 serves as an important marker for studying immune responses and potential therapeutic targets in various diseases.

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CD74 Antibody (OX4) References:

1. Effect of CD74 on the prognosis of patients with resectable pancreatic cancer.  |  Zhang, JF., et al. 2014. Hepatobiliary Pancreat Dis Int. 13: 81-6. PMID: 24463084
2. CD74 interferes with the expression of fas receptor on the surface of lymphoma cells.  |  Berkova, Z., et al. 2014. J Exp Clin Cancer Res. 33: 80. PMID: 25304249
3. CD74 expression and its therapeutic potential in thyroid carcinoma.  |  Cheng, SP., et al. 2015. Endocr Relat Cancer. 22: 179-90. PMID: 25600560
4. CD74 is a T cell antigen in spondyloarthritis.  |  Sogkas, G., et al. 2020. Clin Exp Rheumatol. 38: 195-202. PMID: 31140396
5. CD74 is dispensable for development of chronic lymphocytic leukemia in Eµ-TCL1 transgenic mice.  |  Barthel, R., et al. 2020. Leuk Lymphoma. 61: 2799-2810. PMID: 32667245
6. A deficient MIF-CD74 signaling pathway may play an important role in immunotherapy-induced hyper-progressive disease.  |  Wang, J., et al. 2023. Cell Biol Toxicol. 39: 1169-1180. PMID: 34797429
7. microRNA-501 controls myogenin+/CD74+ myogenic progenitor cells during muscle regeneration.  |  Fahrner, A., et al. 2023. Mol Metab. 71: 101704. PMID: 36907509
8. CD74 is associated with inflamed tumor immune microenvironment and predicts responsiveness to PD-1/CTLA-4 bispecific antibody in patients with solid tumors.  |  Wang, J., et al. 2024. Cancer Immunol Immunother. 73: 36. PMID: 38280003
9. Antibiotic use attenuates response to immune checkpoint blockade in urothelial carcinoma via inhibiting CD74-MIF/COPA: revealing cross-talk between anti-bacterial immunity and anti-tumor immunity through a tumor marker prognostic study.  |  Song, Y., et al. 2024. Int J Surg.. PMID: 38995167
10. IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHCII complexes.  |  Qiu, Z., et al. 2024. Sci Adv. 10: eadk2091. PMID: 38996030

The preferred CD74 antibody is CD74 Antibody (LN-2): sc-6262.