CD74 Antibody (2X31): sc-70781

CD74 Antibody (2X31) is a mouse monoclonal IgG1 antibody that recognizes CD74 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). CD74, also known as the invariant chain, plays a crucial role in the immune system by regulating peptide loading onto major histocompatibility complex class II (MHC II) molecules. This process is vital for proper antigen presentation to T lymphocytes, which is essential for initiating adaptive immune responses. The interaction between CD74 and MHC II occurs during MHC II transport to the endosomal compartment, where peptide binding takes place. CD74 is expressed in various immune cells, particularly in normal B lymphocytes, and CD74 expression is critical for the development and function of these cells. CD74 involvement in immune signaling pathways highlights CD74 importance in maintaining immune homeostasis and responding to pathogens. Anti-CD74 antibody (2X31) serves as an invaluable tool for researchers studying immune responses, antigen presentation, and related cellular processes.

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CD74 Antibody (2X31) References:

1. Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury.  |  Sauler, M., et al. 2015. FASEB J. 29: 1940-9. PMID: 25609432
2. The integral role of CD74 in antigen presentation, MIF signal transduction, and B cell survival and homeostasis.  |  Bucala, R. and Shachar, I. 2014. Mini Rev Med Chem. 14: 1132-8. PMID: 25643611
3. CD74 knockout attenuates alcohol intake-induced cardiac dysfunction through AMPK-Skp2-mediated regulation of autophagy.  |  Yang, L., et al. 2019. Biochim Biophys Acta Mol Basis Dis. 1865: 2368-2378. PMID: 31167126
4. Identification of Chicken CD74 as a Novel Cellular Attachment Receptor for Infectious Bursal Disease Virus in Bursa B Lymphocytes.  |  Liu, A., et al. 2020. J Virol. 94: PMID: 31666381
5. CD74 knockout protects against LPS-induced myocardial contractile dysfunction through AMPK-Skp2-SUV39H1-mediated demethylation of BCLB.  |  Luo, Y., et al. 2020. Br J Pharmacol. 177: 1881-1897. PMID: 31877229
6. CD74 regulates cellularity and maturation of medullary thymic epithelial cells partially by activating the canonical NF-κB signaling pathway.  |  Wang, HX., et al. 2021. FASEB J. 35: e21535. PMID: 33817835
7. Intravesical CD74 and CXCR4, macrophage migration inhibitory factor (MIF) receptors, mediate bladder pain.  |  Ye, S., et al. 2021. PLoS One. 16: e0255975. PMID: 34424927
8. 5-HMF attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis mice by inhibiting the MIF-CD74 interaction.  |  Guan, D., et al. 2023. Acta Biochim Biophys Sin (Shanghai). 55: 1222-1233. PMID: 37431183
9. The role of macrophage migration inhibitory factor family and CD74 in the pathogenesis of melanoma.  |  Tanese, K. and Ogata, D. 2024. Exp Dermatol. 33: e15122. PMID: 38884501
10. CD74-AKT Axis Is a Potential Therapeutic Target in Triple-Negative Breast Cancer.  |  Wang, J., et al. 2024. Biology (Basel). 13: PMID: 39056676

The preferred CD74 antibody is CD74 Antibody (LN-2): sc-6262.