casein kinase Iε Antibody (A-6): sc-374069

Casein kinase Iε Antibody (A-6) is a mouse monoclonal IgG1 antibody that detects casein kinase Iε in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Casein kinase Iε plays a crucial role in various cellular processes, particularly in the regulation of circadian rhythms and cell cycle progression, making casein kinase Iε essential for maintaining cellular homeostasis and responding to environmental cues. Casein kinase Iε is primarily located in the cytoplasm and nucleus, where casein kinase Iε participates in signaling pathways that influence gene expression and cellular proliferation. The localization of casein kinase Iε is significant because this positioning allows for precise modulation of substrates, which include key proteins involved in DNA repair and cell division. By understanding casein kinase Iε dynamics within cells, researchers can gain insights into contributions to cellular function and potential implications in diseases such as cancer, where dysregulation of kinase activity is often observed. Anti-casein kinase Iε antibody (A-6) serves as an invaluable tool for studying these processes and advancing our knowledge of cellular signaling mechanisms.

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casein kinase Iε Antibody (A-6) References:

1. Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon.  |  Vielhaber, E., et al. 2000. Mol Cell Biol. 20: 4888-99. PMID: 10848614
2. Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock.  |  Lee, C., et al. 2004. Mol Cell Biol. 24: 584-94. PMID: 14701732
3. Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.  |  Eide, EJ., et al. 2005. Mol Cell Biol. 25: 2795-807. PMID: 15767683
4. Dual alterations in casein kinase I-epsilon and GSK-3beta modulate beta-catenin stability in hyperproliferating colonic epithelia.  |  Umar, S., et al. 2007. Am J Physiol Gastrointest Liver Physiol. 292: G599-607. PMID: 17053159
5. Casein kinase I epsilon (CKIvarepsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders.  |  Castro, RM., et al. 2008. Behav Brain Res. 193: 156-7. PMID: 18571740
6. Interactions between Casein kinase Iepsilon (CKIepsilon) and two substrates from disparate signaling pathways reveal mechanisms for substrate-kinase specificity.  |  Dahlberg, CL., et al. 2009. PLoS One. 4: e4766. PMID: 19274088
7. TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo.  |  Choksi, DK., et al. 2014. Hum Mol Genet. 23: 1025-35. PMID: 24105464
8. Reciprocal action of Casein Kinase Iε on core planar polarity proteins regulates clustering and asymmetric localisation.  |  Strutt, H., et al. 2019. Elife. 8: PMID: 31090542
9. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.  |  Fish, KJ., et al. 1995. J Biol Chem. 270: 14875-83. PMID: 7797465
10. Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved by protein phosphatases and limited proteolysis.  |  Cegielska, A., et al. 1998. J Biol Chem. 273: 1357-64. PMID: 9430669

The preferred casein kinase Iδ antibody is casein kinase Iδ Antibody (C-8): sc-55553.