Aminopeptidase P1 Antibody (D-7): sc-398955

Aminopeptidase P1 Antibody (D-7) is a mouse monoclonal IgG1 antibody that detects Aminopeptidase P1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Aminopeptidase P1 is a crucial enzyme that plays a significant role in the regulation of bioactive peptides, particularly in the degradation of bradykinin, a peptide that influences blood pressure and inflammation. The enzyme exists in two forms: a membrane-bound variant that is glycosylphosphatidylinositol (GPI)-anchored and a cytosolic form, with the membrane-bound variant predominantly expressed in the pancreas and other tissues. This localization allows Aminopeptidase P1 to interact with various substrates in the extracellular environment, thereby modulating physiological responses. Additionally, Aminopeptidase P1′s proline-specific activity enables cleavage of peptides at the N-terminus, which is essential for the activation or inactivation of numerous signaling molecules. Given Aminopeptidase P1′s involvement in critical biological processes and potential as a therapeutic target for breast cancer, anti-Aminopeptidase P1 antibody (D-7) serves as a valuable tool for researchers investigating this enzyme in health and disease.

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Aminopeptidase P1 Antibody (D-7) References:

1. Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene.  |  Prueitt, RL., et al. 2000. Cytogenet Cell Genet. 89: 44-50. PMID: 10894934
2. Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.  |  Gispert, S., et al. 2013. Hum Mol Genet. 22: 4871-87. PMID: 23851121
3. Deficiency of aminopeptidase P1 causes behavioral hyperactivity, cognitive deficits, and hippocampal neurodegeneration.  |  Bae, YS., et al. 2018. Genes Brain Behav. 17: 126-138. PMID: 28834604
4. Mycoplasma hyopneumoniae surface-associated proteases cleave bradykinin, substance P, neurokinin A and neuropeptide Y.  |  Jarocki, VM., et al. 2019. Sci Rep. 9: 14585. PMID: 31601981
5. M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.  |  Rao, SD., et al. 2022. Nat Chem Biol. 18: 565-574. PMID: 35165443
6. Nepetin reduces virulence factors expression by targeting ClpP against MRSA-induced pneumonia infection.  |  Jing, S., et al. 2022. Virulence. 13: 578-588. PMID: 35363605
7. Suppression of exaggerated NMDAR activity by memantine treatment ameliorates neurological and behavioral deficits in aminopeptidase P1-deficient mice.  |  Bae, YS., et al. 2022. Exp Mol Med. 54: 1109-1124. PMID: 35922532
8. The activated ClpP peptidase forcefully grips a protein substrate.  |  Walker, SD. and Olivares, AO. 2022. Biophys J. 121: 3907-3916. PMID: 36045571
9. Disruption of mitochondrial unfolded protein response results in telomere shortening in mouse oocytes and somatic cells.  |  Cozzolino, M., et al. 2024. Aging (Albany NY). 16: 2047-2060. PMID: 38349865
10. Development of Small Molecular Hyper-activators of Human Caseinolytic Peptidase P (hClpP) with a [1,8]-naphthyridinone Scaffold as Novel Anti-cancer Agents.  |  Fu, Y., et al. 2024. ChemMedChem. e202400528. PMID: 39505831

The preferred Aminopeptidase P1 antibody is Aminopeptidase P1 Antibody (H-4): sc-514272.