ALB/Albumin Antibody (SAB117): sc-69873

ALB Antibody (SAB117) is a mouse monoclonal IgG1 antibody engineered to recognize human serum albumin (ALB), also known as human serum albumin (HSA). ALB monoclonal antibody (SAB117) is validated for use in western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications specifically in human samples. Albumin is the most abundant protein in plasma, synthesized in the liver, and plays a crucial role in maintaining the colloidal osmotic pressure of blood, which is essential for regulating fluid balance between blood vessels and tissues. Structurally, albumin consists of a single polypeptide chain with multiple binding sites, allowing albumin to transport a wide range of ligands including water, fatty acids, calcium, sodium, bilirubin, hormones, potassium, and various drugs. Post-translational modifications of albumin, such as glycation and oxidation, are vital for albumin′s stability and functionality, influencing binding capacity and interaction with other molecules. These modifications ensure effective transport and regulatory functions under different physiological conditions. Additionally, albumin′s ability to bind and transport hormones like thyroxine highlights albumin′s importance in endocrine regulation. Mutations in the ALB gene can lead to disorders such as familial dysalbuminemic hyperthyroxinemia (FDH), which affects thyroid hormone binding and is a significant cause of inherited euthyroid hyperthyroxinemia in certain populations. ALB (SAB117) antibody facilitates research into albumin-related physiological processes and disease mechanisms and serves as an essential tool for biomedical research and diagnostic applications, enabling accurate analysis of albumin′s multifaceted roles in health and disease.

The preferred ALB/Albumin antibody is ALB/Albumin Antibody (F-10): sc-271605.