Keratin 39 Inibidores

Os inibidores comuns da queratina 39 incluem, entre outros, o dimetilsulfóxido (DMSO) CAS 67-68-5, a colchicina CAS 64-86-8, o taxol CAS 33069-62-4, a alsterpaulona CAS 237430-03-4 e a withaferina A CAS 5119-48-2.

Keratin inhibitors 39 consist of compounds such as dimethylsulfoxide and acrylamide that can interact directly with keratin proteins, causing changes in their structure and assembly. This can lead to a wide range of effects on the stability and functionality of the keratin cytoskeleton. Chemical substances such as colchicine and paclitaxel exert their effects on microtubules, components of the cytoskeleton which, when disrupted, can indirectly influence the spatial organization and mechanical properties of keratin filaments. These interactions are important because the cytoskeletal network is an integrated system in which microtubules, actin filaments and intermediate filaments, such as keratins, are interdependent. Similarly, agents such as Alsterpaullone and Withaferin A act on other cellular proteins and signaling pathways that can lead to modifications in the phosphorylation states of keratin and the organization of filaments.

Other members of this chemical class, including retinoic acid and methotrexate, work by modulating cellular processes such as differentiation and proliferation, which can subsequently affect the expression levels and assembly of keratins. Cisplatin, through its role in inducing apoptosis, can lead to changes in cell structure that require the reorganization of the keratin network. In addition, changes in ion concentrations within the cell, influenced by chemicals such as calcium chloride, can alter the assembly dynamics of keratin filaments, since ion balance is fundamental for protein-protein interactions within the cell.