IBA2 is a protein encoded by the PLEKHM1P gene in humans. This gene is also known as "IBA2 pseudogene," indicating that it is a non-functional copy of a gene. Pseudogenes arise from the duplication or mutation of existing genes, and they typically do not produce functional proteins due to accumulated mutations or alterations in their sequences.However, the original functional gene related to IBA2, from which the pseudogene is derived, has significance in biological research. IBA2 generally refers to "Ionized calcium-Binding Adapter molecule 2," which is involved in various cellular processes, particularly in the immune and nervous systems.
In its functional form, IBA2 is known to be involved in the modulation of calcium signaling within cells. Calcium ions are crucial secondary messengers in cellular signaling pathways, influencing processes such as neurotransmission, muscle contraction, and immune responses. Proteins like IBA2 that bind to calcium ions play critical roles in regulating these processes.IBA2 has been particularly studied in the context of the nervous system and immune system. In the nervous system, it is involved in neuronal development and function, influencing synaptic plasticity and neurotransmitter release. In the immune system, IBA2 may participate in the regulation of immune cell function, such as in the activation and response of macrophages and other immune cells.The study of IBA2, therefore, contributes to our understanding of calcium-dependent signaling in various physiological processes and the implications of these processes in health and disease.
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| Nome do Produto | CAS # | Numero de Catalogo | Quantidade | Preco | Uso e aplicacao | NOTAS |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Aumenta a concentração de cálcio extracelular, influenciando potencialmente a sinalização de cálcio mediada pelo IBA2. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
Inibem a calmodulina, uma proteína mensageira de ligação ao cálcio, afectando potencialmente o papel do IBA2 na sinalização do cálcio. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $229.00 | 33 | |
Estabiliza os filamentos de actina, influenciando potencialmente a interação do IBA2 com o citoesqueleto. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Interrompe a polimerização da actina, o que pode influenciar indiretamente o papel do IBA2 na dinâmica da actina. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Estabiliza os filamentos de actina, podendo afetar indiretamente a função do IBA2 relacionada com a reorganização da actina. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $20.00 $62.00 $116.00 $246.00 $799.00 | 23 | |
Um quelante de cálcio, pode modular os níveis de cálcio e influenciar potencialmente a atividade do IBA2. | ||||||
BAPTA, Free Acid | 85233-19-8 | sc-201508 sc-201508A | 100 mg 500 mg | $67.00 $262.00 | 10 | |
Outro quelante de cálcio, utilizado para ligar especificamente iões de cálcio, afectando potencialmente o IBA2. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Inibe a Ca2+ ATPase do retículo sarcoplasmático/endoplasmático (SERCA), alterando a dinâmica do cálcio e afectando o IBA2. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Aumenta a concentração de cálcio intracelular, influenciando potencialmente a atividade do IBA2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Um ionóforo de cálcio, pode aumentar o cálcio intracelular, afectando possivelmente o IBA2. | ||||||