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3′-Sialyllactose sodium salt (CAS 128596-80-5)

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Alternate Names:
3′-N-Acetylneuraminyl-D-lactose sodium slt
Application:
3′-Sialyllactose sodium salt is a compound used to differentiate and characterize binding domains of viruses
CAS Number:
128596-80-5
Purity:
≥90%
Molecular Weight:
655.53
Molecular Formula:
C23H38NO19•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3′-Sialyllactose is a compound that functions as a receptor for certain pathogens, facilitating their attachment to host cells. It plays a role in the initial stages of infection by allowing the pathogen to adhere to the cell surface, a crucial step in the infection process. This compound interacts with specific proteins on the surface of the pathogen, enabling it to recognize and bind to the host cell. This interaction is essential for the pathogen to gain entry into the host cell and initiate infection. At the molecular level, 3′-Sialyllactose acts as a key mediator in the recognition and attachment process, allowing the pathogen to establish a foothold and begin the infection process. Its specific molecular structure enables it to interact with the pathogen′s surface proteins, facilitating the initial stages of infection.


3′-Sialyllactose sodium salt (CAS 128596-80-5) References

  1. Inhibition of Helicobacter pylori adherence by a peptide derived from neuraminyl lactose binding adhesin.  |  Chaturvedi, G., et al. 2001. Mol Cell Biochem. 228: 83-9. PMID: 11855744
  2. Bacteroides forsythus hemagglutinin is inhibited by N-acetylneuraminyllactose.  |  Murakami, Y., et al. 2002. Oral Microbiol Immunol. 17: 125-8. PMID: 11929561
  3. Chymotrypsin and neuraminidase treatment inhibits host cell invasion by Babesia divergens (Phylum Apicomplexa).  |  Zintl, A., et al. 2002. Parasitology. 125: 45-50. PMID: 12166519
  4. Binding of influenza viruses to sialic acids: reassortant viruses with A/NWS/33 hemagglutinin bind to alpha2,8-linked sialic acid.  |  Wu, W. and Air, GM. 2004. Virology. 325: 340-50. PMID: 15246273
  5. Serotype-specific differences in inhibition of reovirus infectivity by human-milk glycans are determined by viral attachment protein σ1.  |  Iskarpatyoti, JA., et al. 2012. Virology. 433: 489-97. PMID: 22999096
  6. Direct and label-free influenza virus detection based on multisite binding to sialic acid receptors.  |  Horiguchi, Y., et al. 2017. Biosens Bioelectron. 92: 234-240. PMID: 28222368
  7. Versatile Methodology for Glycosurfaces: Direct Ligation of Nonderivatized Reducing Saccharides to Poly(pentafluorophenyl acrylate) Grafted Surfaces via Hydrazide Conjugation.  |  Chen, L., et al. 2017. Langmuir. 33: 8821-8828. PMID: 28492327
  8. Toxicological evaluation of 3'-sialyllactose sodium salt.  |  Kim, D., et al. 2018. Regul Toxicol Pharmacol. 94: 83-90. PMID: 29407203
  9. Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples.  |  Lageveen-Kammeijer, GSM., et al. 2019. Nat Commun. 10: 2137. PMID: 31086181
  10. Behaviors and Energy Source of Mycoplasma gallisepticum Gliding.  |  Mizutani, M. and Miyata, M. 2019. J Bacteriol. 201: PMID: 31308069
  11. Toxicological safety assessment of the human-identical milk oligosaccharide 3'-sialyllactose sodium salt.  |  Phipps, KR., et al. 2019. J Appl Toxicol. 39: 1378-1393. PMID: 31418894
  12. Streptococcus pneumoniae pneumolysin and neuraminidase A convert high-density lipoproteins into pro-atherogenic particles.  |  Syed, S., et al. 2021. iScience. 24: 102535. PMID: 34124613
  13. Therapeutic effect of intra-articular injected 3'-sialyllactose on a minipig model of rheumatoid arthritis induced by collagen.  |  Kim, YJ., et al. 2022. Lab Anim Res. 38: 8. PMID: 35314005
  14. Safety of 3'-sialyllactose (3'-SL) sodium salt produced by derivative strains of Escherichia coli BL21 (DE3) as a Novel Food pursuant to Regulation (EU) 2015/2283.  |  , ., et al. 2022. EFSA J. 20: e07331. PMID: 35646166
  15. Bioinformatics analysis of adhesin-binding potential and ADME/Tox profile of anti-Helicobacter pylori peptides derived from wheat germ proteins.  |  Dang, C., et al. 2022. Heliyon. 8: e09629. PMID: 35706937
  16. The Milk Active Ingredient, 2'-Fucosyllactose, Inhibits Inflammation and Promotes MUC2 Secretion in LS174T Goblet Cells In Vitro.  |  Yao, Q., et al. 2023. Foods. 12: PMID: 36613400

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3′-Sialyllactose sodium salt, 50 mg

sc-216626
50 mg
$205.00

What is its pH in an aqueous solution?

Asked by: nemtudomkivagyok
Thank you for your question . We did not test for pH in a aqueous solution .
Answered by: BlakeJ
Date published: 2023-03-24

Hi, I ordered this product to perform a Neuraminidase 1 enzymatic assay, do you have any protocol? thx

Asked by: rmosca
Thank you very much for your question. We are unable to provide a protocol to perform an enzymatic assay. But I hope you find this information helpful: PMID: 11855744 PMID: 11929561 PMID: 12166519 PMID: 15246273 PMID: 22999096 Please do not hesitate to contact us if you have any further question: scbt@scbt.com
Answered by: Technical Support Europe
Date published: 2017-12-29

Is this a mix of isomers?

Asked by: SCchem16
Thank you for your question. 3’-Sialyllactose sodium salt, sc-216626, is an anomeric a/b mixture.
Answered by: TechService7
Date published: 2017-01-11
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Rated 5 out of 5 by from Various publications cite the use of 3Various publications cite the use of 3 -Sialyllactose sodium salt to differentiate and characterize binding domains of viruses. -SCBT Publication Review
Date published: 2015-04-13
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3′-Sialyllactose sodium salt is rated 5.0 out of 5 by 1.
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