ZNF862 Antibody (A-6): sc-398768

ZNF862 Antibody (A-6) is a mouse monoclonal IgM antibody that detects ZNF862 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ZNF862 antibody (A-6) is available as the non-conjugated form. ZNF862, also known as zinc finger protein 862, is a crucial nuclear protein composed of 1,169 amino acids that plays a significant role in transcriptional regulation. ZNF862 belongs to the Krüppel C2H2-type zinc-finger protein family, characterized by thirteen C2H2-type zinc fingers and a KRAB domain, which is believed to interact with KAP1, facilitating the recruitment of histone-modifying proteins that influence chromatin structure and gene expression. Proper functioning of ZNF862 is vital for maintaining normal cellular processes, as dysregulation can lead to various genetic disorders. ZNF862 is encoded on human chromosome 7, a region associated with several genetic conditions, including Osteogenesis imperfecta and Shwachman-Diamond syndrome. Notably, deletions in this chromosome have been linked to Williams-Beuren syndrome, which presents with cognitive challenges and distinctive physical features. ZNF862′s ability to modulate transcriptional activity underscores its importance in cellular homeostasis and highlights the potential implications of its dysfunction in disease states.

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ZNF862 Antibody (A-6) References:

1. Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB.  |  Han, ZG., et al. 1999. J Biol Chem. 274: 35741-8. PMID: 10585455
2. Long-term audiological feature in Pendred syndrome caused by PDS mutation.  |  Iwasaki, S., et al. 2001. Arch Otolaryngol Head Neck Surg. 127: 705-8. PMID: 11405873
3. Williams-Beuren syndrome diagnosis using fluorescence in situ hybridization.  |  Osborne, LR., et al. 2006. Methods Mol Med. 126: 113-28. PMID: 16930009
4. Lissencephaly 1 linking to multiple diseases: mental retardation, neurodegeneration, schizophrenia, male sterility, and more.  |  Reiner, O., et al. 2006. Neuromolecular Med. 8: 547-65. PMID: 17028375
5. [Williams-Beuren syndrome].  |  Gilbert-Dussardier, B. 2006. Rev Prat. 56: 2102-6. PMID: 17416045
6. Therapy-related leukemia and myelodysplasia: susceptibility and incidence.  |  Leone, G., et al. 2007. Haematologica. 92: 1389-98. PMID: 17768113
7. Context-dependent DNA recognition code for C2H2 zinc-finger transcription factors.  |  Liu, J. and Stormo, GD. 2008. Bioinformatics. 24: 1850-7. PMID: 18586699
8. Multiple genes encoding zinc finger domains are expressed in human T cells.  |  Thiesen, HJ. 1990. New Biol. 2: 363-74. PMID: 2288909
9. Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta.  |  Tsipouras, P., et al. 1983. J Clin Invest. 72: 1262-7. PMID: 6313757
10. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs.  |  Rosenfeld, R. and Margalit, H. 1993. J Biomol Struct Dyn. 11: 557-70. PMID: 8129873
11. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19.  |  Rousseau-Merck, MF., et al. 1993. Hum Genet. 92: 583-7. PMID: 8262519
12. Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci.  |  Liang, H., et al. 1998. Proc Natl Acad Sci U S A. 95: 3781-5. PMID: 9520444

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF862 Antibody (A-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF862 Antibody (A-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF862 Antibody (A-6) Specifications

Alternate Product Name: ZNF862

Product Clone Name: A-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1068-1096

Epitope Target: ZNF862

Epitope Species: human

Product Reactivity/Detection: ZNF862

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZNF862 Antibody (A-6): P: Blocking Peptide