ZNF70 Antibody (F-8): sc-398828
- ZNF70 Antibody (F-8) is a mouse monoclonal IgG2a κ ZNF70 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 26-41 near the N-terminus of ZNF70 of human origin
- ZNF70 Antibody (F-8) is recommended for detection of ZNF70 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ZNF70 Antibody (F-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-398828 X, 200 µg/0.1 ml)
- m-IgG2a BP-HRP is the preferred secondary detection reagent for ZNF70 Antibody (F-8) for WB applications. This reagent is now offered in a bundle with ZNF70 Antibody (F-8) (see ordering information below).
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ZNF70 Antibody (F-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects ZNF70 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZNF70 (F-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZNF70, also known as Zinc finger protein N27C7-1, is a crucial nuclear protein composed of 446 amino acids and features eleven C2H2-type zinc fingers, which are essential for DNA binding and transcriptional regulation. Located primarily in the nucleus, ZNF70 plays a significant role in gene expression modulation, which is vital for cellular processes such as differentiation and response to environmental stimuli. The presence of zinc fingers allows ZNF70 to interact with specific DNA sequences, thereby influencing the transcription of target genes. Additionally, ZNF70 is implicated in various biological pathways, and dysfunction has been associated with several genetic disorders linked to chromosome 22, including Phelan-McDermid syndrome and neurofibromatosis type 2. Using anti-ZNF70 antibody (F-8) in research can provide insights into regulatory mechanisms of gene expression and potential implications of ZNF70 in disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ZNF70 Antibody (F-8) References:
- Chromosome 22 workshop report. | Schwab, SG. and Wildenauer, DB. 1999. Am J Med Genet. 88: 276-8. PMID: 10374745
- Disease genes and chromosomes: disease maps of the human genome. Chromosome 22. | Gilbert, F. 1998. Genet Test. 2: 89-97. PMID: 10464604
- Zinc finger proteins: new insights into structural and functional diversity. | Laity, JH., et al. 2001. Curr Opin Struct Biol. 11: 39-46. PMID: 11179890
- Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). | Aubry, M., et al. 1992. Genomics. 13: 641-8. PMID: 1639391
- Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia. | Arinami, T. 2006. J Hum Genet. 51: 1037-1045. PMID: 16969581
- Sticky fingers: zinc-fingers as protein-recognition motifs. | Gamsjaeger, R., et al. 2007. Trends Biochem Sci. 32: 63-70. PMID: 17210253
- Multiple genes encoding zinc finger domains are expressed in human T cells. | Thiesen, HJ. 1990. New Biol. 2: 363-74. PMID: 2288909
- Finger proteins and DNA-specific recognition: distinct patterns of conserved amino acids suggest different evolutionary modes. | Payre, F. and Vincent, A. 1988. FEBS Lett. 234: 245-50. PMID: 3292287
- Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. | Rosenfeld, R. and Margalit, H. 1993. J Biomol Struct Dyn. 11: 557-70. PMID: 8129873
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZNF70 Antibody (F-8) | sc-398828 | 200 µg/ml | $322.00 | |||
ZNF70 Antibody (F-8): m-IgG2a BP-HRP Bundle | sc-545974 | 200 µg Ab; 10 µg BP | $361.00 | |||
ZNF70 Antibody (F-8) X | sc-398828 X | 200 µg/0.1 ml | $322.00 | |||
ZNF70 Antibody (F-8) AC | sc-398828 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ZNF70 Antibody (F-8) HRP | sc-398828 HRP | 200 µg/ml | $322.00 | |||
ZNF70 Antibody (F-8) FITC | sc-398828 FITC | 200 µg/ml | $336.00 | |||
ZNF70 Antibody (F-8) PE | sc-398828 PE | 200 µg/ml | $349.00 | |||
ZNF70 Antibody (F-8) Alexa Fluor® 488 | sc-398828 AF488 | 200 µg/ml | $364.00 | |||
ZNF70 Antibody (F-8) Alexa Fluor® 546 | sc-398828 AF546 | 200 µg/ml | $364.00 | |||
ZNF70 Antibody (F-8) Alexa Fluor® 594 | sc-398828 AF594 | 200 µg/ml | $364.00 | |||
ZNF70 Antibody (F-8) Alexa Fluor® 647 | sc-398828 AF647 | 200 µg/ml | $364.00 | |||
ZNF70 Antibody (F-8) Alexa Fluor® 680 | sc-398828 AF680 | 200 µg/ml | $364.00 | |||
ZNF70 Antibody (F-8) Alexa Fluor® 790 | sc-398828 AF790 | 200 µg/ml | $364.00 | |||
ZNF70 (F-8) Neutralizing Peptide | sc-398828 P | 100 µg/0.5 ml | $69.00 |