ZNF622 Antibody (3I4): sc-100980

ZNF622 Antibody (3I4) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZNF622 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ZNF622 antibody (3I4) is available as the non-conjugated format. ZNF622, also known as Zinc finger protein 622 or ZPR9, is a 477 amino acid protein that plays a crucial role in cellular processes by localizing to both the nucleus and cytoplasm. This dual localization enables ZNF622 to participate in various regulatory functions, including the activation of transcription factors such as B-Myb, which is essential for embryonic development. The presence of two U1-type zinc fingers in ZNF622′s structure enables DNA binding, influencing gene expression and cellular differentiation. ZNF622 can form homodimers or heterodimers and undergoes phosphorylation by Maternal embryonic leucine zipper kinase (MELK), which may further modulate activity and interactions within the cell. Notably, overexpression of ZNF622 has been linked to liver metastases, carcinomatoses, and colorectal carcinomas, highlighting potential role in cancer biology and making ZNF622 a valuable target for research and therapeutic applications.

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ZNF622 Antibody (3I4) References:

1. Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38).  |  Seong, HA., et al. 2002. Biochem J. 361: 597-604. PMID: 11802789
2. Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein.  |  Seong, HA., et al. 2003. J Biol Chem. 278: 9655-62. PMID: 12645566
3. Nucleolar proteome dynamics.  |  Andersen, JS., et al. 2005. Nature. 433: 77-83. PMID: 15635413
4. Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses.  |  Kleivi, K., et al. 2007. Mol Cancer. 6: 2. PMID: 17201907
5. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.  |  Huebner, K., et al. 1991. Am J Hum Genet. 48: 726-40. PMID: 2014798
6. Multiple genes encoding zinc finger domains are expressed in human T cells.  |  Thiesen, HJ. 1990. New Biol. 2: 363-74. PMID: 2288909

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF622 Antibody (3I4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF622 Antibody (3I4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF622 Antibody (3I4) Specifications

Alternate Product Name: ZNF622

Product Clone Name: 3I4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-101

Epitope Target: ZNF622

Epitope Species: human

Product Reactivity/Detection: ZNF622

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ZNF622 Antibody (3I4): N/A