XRCC1 Antibody (AP-39): sc-517377
- XRCC1 Antibody (AP-39) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to XRCC1 of human origin
- recommended for detection of XRCC1 of human origin by WBIP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for XRCC1 Antibody (AP-39). This work is in progress.
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XRCC1 Antibody (AP-39) is a mouse monoclonal IgG1 antibody that detects XRCC1 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. XRCC1 plays a crucial role in the DNA base excision repair pathway, which is essential for maintaining genomic integrity by repairing single-strand breaks in DNA. XRCC1 acts as a scaffold that facilitates the recruitment of various DNA repair proteins, including DNA ligase III and DNA polymerase, thereby ensuring efficient repair processes. The importance of XRCC1 is underscored by its involvement in preventing mutations that could lead to cancer and other genetic disorders. Additionally, defects in XRCC1 can compromise the DNA repair mechanism, leading to increased susceptibility to DNA damage and contributing to the development of various diseases. Anti-XRCC1 antibody (AP-39) is an invaluable tool for researchers studying DNA repair mechanisms and their implications in human health.
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XRCC1 Antibody (AP-39) References:
- A meta-analysis of an association between the XRCC1 polymorphisms and gliomas risk. | Li, M., et al. 2013. J Neurooncol. 111: 221-8. PMID: 23238971
- The structural basis of XRCC1-mediated DNA repair. | London, RE. 2015. DNA Repair (Amst). 30: 90-103. PMID: 25795425
- XRCC1 and OGG1 Gene Polymorphisms and Breast Cancer: A Systematic Review of Literature. | Sanjari Moghaddam, A., et al. 2016. Iran J Cancer Prev. 9: e3467. PMID: 27366307
- XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity. | Horton, JK., et al. 2018. DNA Repair (Amst). 64: 26-33. PMID: 29477978
- HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation. | Kumamoto, S., et al. 2021. Nucleic Acids Res. 49: 5003-5016. PMID: 33872376
- XRCC1 prevents toxic PARP1 trapping during DNA base excision repair. | Demin, AA., et al. 2021. Mol Cell. 81: 3018-3030.e5. PMID: 34102106
- XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair. | Adamowicz, M., et al. 2021. Nat Cell Biol. 23: 1287-1298. PMID: 34811483
- XRCC1: a potential prognostic and immunological biomarker in LGG based on systematic pan-cancer analysis. | Wang, G., et al. 2024. Aging (Albany NY). 16: 872-910. PMID: 38217545
- TRIM25-mediated XRCC1 ubiquitination accelerates atherosclerosis by inducing macrophage M1 polarization and programmed death. | Wu, H., et al. 2024. Inflamm Res. 73: 1445-1458. PMID: 38896288
- Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma. | Li, G., et al. 2024. Cell Metab. 36: 1696-1710.e10. PMID: 39111285
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
XRCC1 Antibody (AP-39) | sc-517377 | 100 µg/ml | $322.00 |