XL 388 CAS: 1251156-08-7
MF: C23H22FN3O4S
MW: 455.50
CAS: 1251156-08-7. MW: 455.50. MF: C23H22FN3O4S..

XL 388 (CAS 1251156-08-7)

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Alternate Names: [7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone
Application: CAS: 1251156-08-7. MW: 455.50. MF: C23H22FN3O4S.
CAS Number: 1251156-08-7
Molecular Weight: 455.50
Molecular Formula: C23H22FN3O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

XL 388 is a mTOR inhibitor that inhibits in an ATP-competitive manner. Exhibits >300-fold selectivity for mTOR over PI 3-K and a range of other kinases. Displays antitumor activity in athymic nude mice implanted with tumor xenografts.

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mM).
Storage :
Store at -20° C
Boiling Point :
~738.6° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
mTOR: IC50 = 9.9 nM; PI 3-kinase p110α: IC50 >3 µM (human); Flk-1: IC50 >3.5 µM (human); c-Src: IC50 >3.5 µM (human); PDK1: IC50 >3.5 µM (human)
pK Values :
pKa: 8.12 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD24386875
SMILES :
CC1=C(C=CC(=C1F)S(=O)(=O)C)C(=O)N2CCOC3=C(C2)C=C(C=C3)C4=CN=C(C=C4)N

Download SDS (MSDS)

Certificate of Analysis

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XL 388 (CAS 1251156-08-7)  Product Citations

See how others have used XL 388 (CAS 1251156-08-7). Click on the entry to view the PubMed entry .

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PMID: # 29750888  Physiol Res. 563-570.

Citations 1 to 1 of 1 total
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