XL 388 (CAS 1251156-08-7)

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Alternate Names: [7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone

Application: CAS: 1251156-08-7. MW: 455.50. MF: C23H22FN3O4S.

CAS Number: 1251156-08-7

Molecular Weight: 455.50

Molecular Formula: C₂₃H₂₂FN₃O₄S

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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XL 388 is a mTOR inhibitor that inhibits in an ATP-competitive manner. Exhibits >300-fold selectivity for mTOR over PI 3-K and a range of other kinases. Displays antitumor activity in athymic nude mice implanted with tumor xenografts.

Physical State :

Solid

Solubility :

Soluble in DMSO (50 mM).

Storage :

Store at -20° C

Boiling Point :

~738.6° C at 760 mmHg (Predicted)

Density :

~1.4 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.62 (Predicted)

IC50 :

mTOR: IC₅₀ = 9.9 nM; PI 3-kinase p110α: IC₅₀ >3 µM (human); Flk-1: IC₅₀ >3.5 µM (human); c-Src: IC₅₀ >3.5 µM (human); PDK1: IC₅₀ >3.5 µM (human)

pK Values :

pK_a: 8.12 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

59604787

MDL Number :

MFCD24386875

SMILES :

CC1=C(C=CC(=C1F)S(=O)(=O)C)C(=O)N2CCOC3=C(C2)C=C(C=C3)C4=CN=C(C=C4)N

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Certificate of Analysis

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XL 388 (CAS 1251156-08-7) Product Citations

See how others have used XL 388 (CAS 1251156-08-7). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 29750888 Physiol Res. 563-570.

Citations 1 to 1 of 1 total

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