Molecular structure of WAY-100135, CAS Number: 149055-79-8
WAY-100135 (CAS 149055-79-8)
Application:
WAY-100135 is a selective and potent SR-1A (5-HT1A receptor) antagonist
CAS Number:
149055-79-8
Molecular Weight:
468.46
Molecular Formula:
C24H33N3O2•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
WAY-100135 is a selective antagonist of the 5-HT6 serotonin receptor. It functions by binding to the receptor and blocking the action of serotonin, a neurotransmitter involved in various physiological processes. By inhibiting the 5-HT6 receptor, WAY-100135 modulates the release of other neurotransmitters, such as dopamine and acetylcholine, in the brain. This modulation can potentially impact cognitive function and memory processes. At the molecular level, WAY-100135′s interaction with the 5-HT6 receptor alters intracellular signaling pathways, leading to downstream effects on neuronal activity. WAY-100135′s mode of action involves targeting the 5-HT6 receptor and interfering with its normal function, potentially influencing cognitive processes in experimental models.
WAY-100135 (CAS 149055-79-8) References
- WAY 100135, an antagonist of 5-HT1A serotonin receptors, attenuates psychotomimetic effects of MK-801. | Wedzony, K., et al. 2000. Neuropsychopharmacology. 23: 547-59. PMID: 11027920
- Role of nitric oxide on motor behavior. | Del Bel, EA., et al. 2005. Cell Mol Neurobiol. 25: 371-92. PMID: 16047547
- Development of theta rhythm in hippocampal formation slices perfused with 5-HT1A antagonist, (S)WAY 100135. | Kazmierska, P. and Konopacki, J. 2015. Brain Res. 1625: 142-50. PMID: 26358147
- (S)-WAY 100135, a 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine. | Carli, M., et al. 1995. Eur J Pharmacol. 283: 133-9. PMID: 7498302
- Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190. | Routledge, C., et al. 1995. Eur J Pharmacol. 276: 281-4. PMID: 7601215
- Antagonism of (+)WAY 100135 to behavioral, hypothermic and corticosterone effects induced by 8-OH-DPAT. | Przegaliński, E., et al. 1994. Pol J Pharmacol. 46: 21-7. PMID: 7981767
- The novel selective and silent 5-HT1A receptor antagonist (+)-WAY-100135 aggravates dystonic movements in a mutant hamster model. | Löscher, W. and Richter, A. 1994. Eur J Pharmacol. 255: 235-8. PMID: 8026548
- The effects of WAY-100135 and 8-hydroxy-2-(di-n-propylamino)tetralin on feeding in the rat. | Hartley, JE. and Fletcher, A. 1994. Eur J Pharmacol. 252: 329-32. PMID: 8162954
- The antagonist actions of WAY-100135 and its enantiomers on 5-HT1A receptor-mediated hyperpolarization of the rat isolated superior cervical ganglion. | Rhodes, KF., et al. 1993. Naunyn Schmiedebergs Arch Pharmacol. 348: 225-7. PMID: 8232599
- Characterization of the serotonin1A receptor antagonist activity of WAY-100135 and spiperone. | Escandon, NA., et al. 1994. J Pharmacol Exp Ther. 268: 441-7. PMID: 8301586
- Effects of the 5-HT1A antagonist (+)-WAY-100135 on murine social and agonistic behavior. | Bell, R., et al. 1996. Pharmacol Biochem Behav. 54: 159-67. PMID: 8728553
- WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135. | Fornal, CA., et al. 1996. J Pharmacol Exp Ther. 278: 752-62. PMID: 8768728
- (+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors. | Davidson, C., et al. 1997. Br J Pharmacol. 121: 737-42. PMID: 9208142
- Effect of WAY-100135 on the hippocampal acetylcholine release potentiated by 8-OH-DPAT, a serotonin1A receptor agonist, in normal and p-chlorophenylalanine-treated rats as measured by in vivo microdialysis. | Nakai, K., et al. 1998. Neurosci Res. 31: 23-9. PMID: 9704975
- GR 127935 and (+)-WAY 100135 do not affect TFMPP-induced inhibition of 5-HT synthesis in the midbrain and hippocampus of Wistar-Kyoto rats. | Chaouloff, F., et al. 1998. Neuropharmacology. 37: 1159-67. PMID: 9833646
Inhibitor of:
Serotonin, and SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WAY-100135, 5 mg | sc-364647 | 5 mg | $92.00 | |||
WAY-100135, 25 mg | sc-364647A | 25 mg | $399.00 |