Date published: 2025-10-15

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VU 0238429 (CAS 1160247-92-6)

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Alternate Names:
1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
CAS Number:
1160247-92-6
Molecular Weight:
351.28
Molecular Formula:
C17H12F3NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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VU 0238429 is a chemical that functions as a potent and selective inhibitor of a specific enzyme. It acts by binding to the active site of the enzyme, preventing its normal function and leading to the inhibition of the biochemical pathway it is involved in. This inhibition results in the modulation of cellular processes related to the targeted enzyme, ultimately affecting the biological responses under investigation. VU 0238429′s mode of action involves disrupting the enzyme′s catalytic activity, thereby interfering with the normal progression of cellular signaling pathways. This interference at the molecular level allows for the investigation of the enzyme′s role in various cellular processes and the potential impact of its inhibition on cellular function. VU 0238429 useful for studying the specific enzyme′s function and its involvement in cellular pathways, providing insights into potential targets and mechanisms of action.


VU 0238429 (CAS 1160247-92-6) References

  1. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.  |  Bridges, TM., et al. 2009. J Med Chem. 52: 3445-8. PMID: 19438238
  2. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.  |  Bridges, TM., et al. 2010. Bioorg Med Chem Lett. 20: 558-62. PMID: 20004578
  3. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.  |  Bridges, TM., et al. 2010. Bioorg Med Chem Lett. 20: 5617-22. PMID: 20801651
  4. Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia.  |  Jones, CK., et al. 2012. Neuropsychopharmacology. 37: 16-42. PMID: 21956443
  5. Muscarinic receptors: their roles in disorders of the central nervous system and potential as therapeutic targets.  |  Scarr, E. 2012. CNS Neurosci Ther. 18: 369-79. PMID: 22070219
  6. Muscarinic receptor M3 mediates human gallbladder contraction through voltage-gated Ca2+ channels and Rho kinase.  |  Lee, MC., et al. 2013. Scand J Gastroenterol. 48: 205-12. PMID: 23227858
  7. Synaptic muscarinic response types in hippocampal CA1 interneurons depend on different levels of presynaptic activity and different muscarinic receptor subtypes.  |  Bell, LA., et al. 2013. Neuropharmacology. 73: 160-73. PMID: 23747570
  8. Presynaptic M3 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in area CA1 of rat hippocampus.  |  de Vin, F., et al. 2015. Brain Res. 1629: 260-9. PMID: 26505913
  9. Simultaneous activation of mGlu2 and muscarinic receptors reverses MK-801-induced cognitive decline in rodents.  |  Cieślik, P., et al. 2020. Neuropharmacology. 174: 107866. PMID: 31785263
  10. Acetylcholine Receptor Stimulation Activates Protein Kinase C Mediated Internalization of the Dopamine Transporter.  |  Underhill, SM. and Amara, SG. 2021. Front Cell Neurosci. 15: 662216. PMID: 33897375
  11. Serotonergic-Muscarinic Interaction within the Prefrontal Cortex as a Novel Target to Reverse Schizophrenia-Related Cognitive Symptoms.  |  Cieślik, P., et al. 2021. Int J Mol Sci. 22: PMID: 34445318

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

VU 0238429, 5 mg

sc-301975
5 mg
$74.00

VU 0238429, 25 mg

sc-301975A
25 mg
$297.00