Von Hippel Lindau/VHL Antibody (D-11): sc-514907
- Von Hippel Lindau/VHL Antibody (D-11) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 154-181 at the C-terminus of VHL of rat origin
- recommended for detection of VHL of mouse and rat origin by WB, IP, IF and ELISA
- See Von Hippel Lindau/VHL (D-7): sc-55506 for Von Hippel Lindau/VHL antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG3 BP-HRP is the preferred secondary detection reagent for Von Hippel Lindau/VHL Antibody (D-11) for WB applications. This reagent is now offered in a bundle with Von Hippel Lindau/VHL Antibody (D-11) (see ordering information below).
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SEE ALSO...
VHL Antibody (D-11) is a mouse monoclonal IgG3 antibody that detects von Hippel-Lindau (VHL) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-VHL antibody (D-11) plays a crucial role in cancer research, particularly due to VHL′s association with the tumor suppressor gene that, when mutated, increases susceptibility to various tumors, including renal carcinoma and hemangioblastoma. VHL protein is essential for regulating the hypoxia-inducible factor (HIF) pathway, which is vital for cellular responses to oxygen levels. By promoting HIF degradation under normoxic conditions, VHL helps maintain cellular homeostasis and prevent tumorigenesis. VHL′s interaction with the Elongin (SIII) complex, which consists of Elongin A, B, and C, is critical for function, as VHL binds to the regulatory subunits, thereby inhibiting their transcriptional activity. Understanding VHL structure and function is important for developing targeted therapies and diagnostic tools for VHL-related tumors, making VHL (D-11) monoclonal antibody an invaluable resource for researchers studying these pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Von Hippel Lindau/VHL Antibody (D-11) | sc-514907 | 200 µg/ml | $316.00 | |||
Von Hippel Lindau/VHL Antibody (D-11): m-IgG3 BP-HRP Bundle | sc-550522 | 200 µg Ab; 40 µg BP | $354.00 | |||
Von Hippel Lindau/VHL (D-11) Neutralizing Peptide | sc-514907 P | 100 µg/0.5 ml | $68.00 |