Molecular structure of VEGFR Tyrosine Kinase Inhibitor III, KRN633, CAS Number: 286370-15-8
VEGFR Tyrosine Kinase Inhibitor III, KRN633 (CAS 286370-15-8)
See product citations (5)
Application:
VEGFR Tyrosine Kinase Inhibitor III, KRN633 is an ATP-competitive inhibitor of VEGFR (Flt and Flk) kinase
CAS Number:
286370-15-8
Purity:
≥97%
Molecular Weight:
416.9
Molecular Formula:
C20H21ClN4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
VEGFR Tyrosine Kinase Inhibitor III, KRN633 (VEGF-R-TKI III) represents a groundbreaking small molecule inhibitor. VEGFR Tyrosine Kinase Inhibitor III, KRN633 operates by specifically binding to and inhibiting the tyrosine kinase activity of VEGF receptor tyrosine kinase inhibitor III. This kinase, responsible for initiating downstream signaling pathways that modulate angiogenesis, tumor growth, and inflammation, is effectively neutralized upon VEGFR Tyrosine Kinase Inhibitor III, KRN633 binding. Consequently, the activation of downstream signaling pathways is thwarted, effectively suppressing the effects of VEGF receptor tyrosine kinase inhibitor III signaling.
VEGFR Tyrosine Kinase Inhibitor III, KRN633 (CAS 286370-15-8) References
- KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth. | Nakamura, K., et al. 2004. Mol Cancer Ther. 3: 1639-49. PMID: 15634658
- Improvement by solid dispersion of the bioavailability of KRN633, a selective inhibitor of VEGF receptor-2 tyrosine kinase, and identification of its potential therapeutic window. | Matsunaga, N., et al. 2006. Mol Cancer Ther. 5: 80-8. PMID: 16432165
- Effects of KRN633, an inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase, on vascular development of placenta and fetus of mid-pregnancy in mice. | Wada, Y., et al. 2010. J Pharmacol Sci. 112: 290-8. PMID: 20197639
- Suppression of hypoxia-induced HIF-1alpha accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633. | Ban, HS., et al. 2010. Cancer Lett. 296: 17-26. PMID: 20378243
- Role of protein kinase C β and vascular endothelial growth factor receptor in malignant pleural mesothelioma: Therapeutic implications and the usefulness of Caenorhabditis elegans model organism. | Loganathan, S., et al. 2011. J Carcinog. 10: 4. PMID: 21383961
- KRN633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, induces intrauterine growth restriction in mice. | Abe, N., et al. 2013. Birth Defects Res B Dev Reprod Toxicol. 98: 297-303. PMID: 23780833
- Effects of pre- and post-natal treatment with KRN633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, on retinal vascular development and patterning in mice. | Morita, A., et al. 2014. Exp Eye Res. 120: 127-37. PMID: 24462631
- Effects of mTOR inhibition on normal retinal vascular development in the mouse. | Yagasaki, R., et al. 2014. Exp Eye Res. 129: 127-34. PMID: 25446323
- Treatment of newborn mice with inhibitors of vascular endothelial growth factor receptor tyrosine kinase induces abnormal retinal vascular patterning. | Morita, A., et al. 2014. Biol Pharm Bull. 37: 1986-9. PMID: 25451848
- Short-term treatment with VEGF receptor inhibitors induces retinopathy of prematurity-like abnormal vascular growth in neonatal rats. | Nakano, A., et al. 2016. Exp Eye Res. 143: 120-31. PMID: 26500193
- Attenuation of Retinal Endothelial Vasodilator Function in a Rat Model of Retinopathy of Prematurity. | Nakano, A., et al. 2019. Curr Eye Res. 44: 1360-1368. PMID: 31317786
- Abnormal Vascular Phenotypes Associated with the Timing of Interruption of Retinal Vascular Development in Rats. | Kondo, R., et al. 2020. Biol Pharm Bull. 43: 859-863. PMID: 32378561
- Platelet-rich plasma affects gap junctional features in myofibroblasts in vitro via vascular endothelial growth factor (VEGF)-A/VEGF receptor. | Sassoli, C., et al. 2022. Exp Physiol. 107: 106-121. PMID: 34935228
Inhibitor of:
Angiogenesis, c-Kit, Flk-1, Flt-1, Flt-4, PDGFR-alpha, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VEGFR Tyrosine Kinase Inhibitor III, KRN633, 1 mg | sc-204379 | 1 mg | $173.00 |