vanin-1 Antibody (407): sc-23907
- vanin-1 Antibody (407) is a rat monoclonal IgG1 provided at 200 µg/ml
- raised against mouse thymic stromal cell lines (MTE)
- vanin-1 Antibody (407) is recommended for detection of Vanin-1 of mouse origin by WB, IP, IF and FCM
- Anti-vanin-1 Antibody (407) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for vanin-1 Antibody (407). This work is in progress.
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vanin-1 Antibody (407) is a rat monoclonal IgG1 antibody that detects Vanin-1 of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). vanin-1 (407) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Vanin-1 plays a crucial role as a membrane-bound pantetheinase enzyme, primarily involved in the hydrolysis of pantetheine, which is essential for the recycling of vitamin B5. This enzymatic activity not only facilitates the regeneration of an important nutrient but also produces cysteamine, a potent antioxidant that contributes to cellular protection under normal physiological conditions. The expression of Vanin-1 is particularly significant in male Sertoli cells of the developing testis, where Vanin-1 aids in the migration of precursor cells, highlighting its importance in reproductive health. Additionally, Vanin-1 is found in various human tissues, including the spleen, liver, and small intestine, suggesting Vanin-1′s involvement in vitamin B5 salvage pathways. The gene encoding human Vanin-1 is located on chromosome 6q23-q24, and Vanin-1 is part of a family that includes vanin-2 and vanin-3, which may have overlapping or distinct biological functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
vanin-1 Antibody (407) References:
- Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development. | Grimmond, S., et al. 2000. Hum Mol Genet. 9: 1553-60. PMID: 10888606
- A subtractive gene expression screen suggests a role for vanin-1 in testis development in mice. | Bowles, J., et al. 2000. Genesis. 27: 124-35. PMID: 10951505
- Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice. | Pitari, G., et al. 2000. FEBS Lett. 483: 149-54. PMID: 11042271
- Vanin 1: Its Physiological Function and Role in Diseases. | Bartucci, R., et al. 2019. Int J Mol Sci. 20: PMID: 31404995
- Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease. | Unterschemmann, K., et al. 2021. Am J Physiol Renal Physiol. 320: F61-F73. PMID: 33196323
- Association of urinary vanin-1 with kidney function decline in hypertensive patients. | Hosohata, K., et al. 2021. J Clin Hypertens (Greenwich). 23: 1316-1321. PMID: 34029440
- Visualization-Based Discovery of Vanin-1 Inhibitors for Colitis. | Wang, G., et al. 2021. Front Chem. 9: 809495. PMID: 35155380
- Vanin 1 Gene Role in Modulation of iNOS/MCP-1/TGF-β1 Signaling Pathway in Obese Diabetic Patients. | Mosaad, YO., et al. 2022. J Inflamm Res. 15: 6745-6759. PMID: 36540060
- Urinary vanin-1, tubular injury, and graft failure in kidney transplant recipients. | Alkaff, FF., et al. 2024. Sci Rep. 14: 2283. PMID: 38280883
- The enzymatic breakdown of pantethine to pantothenic acid and cystamine. | Duprè, S., et al. 1970. Eur J Biochem. 16: 571-8. PMID: 5477303
- Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing. | Aurrand-Lions, M., et al. 1996. Immunity. 5: 391-405. PMID: 8934567
- Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. | Galland, F., et al. 1998. Genomics. 53: 203-13. PMID: 9790769
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
vanin-1 Antibody (407) | sc-23907 | 200 µg/ml | $322.00 | |||
vanin-1 Antibody (407) AC | sc-23907 AC | 500 µg/ml, 25% agarose | $424.00 | |||
vanin-1 Antibody (407) HRP | sc-23907 HRP | 200 µg/ml | $322.00 | |||
vanin-1 Antibody (407) FITC | sc-23907 FITC | 200 µg/ml | $336.00 | |||
vanin-1 Antibody (407) PE | sc-23907 PE | 200 µg/ml | $349.00 | |||
vanin-1 Antibody (407) Alexa Fluor® 488 | sc-23907 AF488 | 200 µg/ml | $364.00 | |||
vanin-1 Antibody (407) Alexa Fluor® 546 | sc-23907 AF546 | 200 µg/ml | $364.00 | |||
vanin-1 Antibody (407) Alexa Fluor® 594 | sc-23907 AF594 | 200 µg/ml | $364.00 | |||
vanin-1 Antibody (407) Alexa Fluor® 647 | sc-23907 AF647 | 200 µg/ml | $364.00 | |||
vanin-1 Antibody (407) Alexa Fluor® 680 | sc-23907 AF680 | 200 µg/ml | $364.00 | |||
vanin-1 Antibody (407) Alexa Fluor® 790 | sc-23907 AF790 | 200 µg/ml | $364.00 |