Urothelium Antibody (LBS 8): sc-53460

Urothelium Antibody (LBS 8) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Urothelium protein of human origin by immunofluorescence (IF). Urothelium (LBS 8) monoclonal antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Urothelium is a specialized epithelial layer that lines the urinary tract, including the renal pelvis, ureters, bladder, and parts of the urethra. This specialized layer serves as a permeability barrier, protecting underlying tissues from harmful substances in urine while also allowing for the distension necessary to accommodate varying urine volumes. Urothelium consists of 3-5 cell layers and features a unique luminal surface covered with protective glycoprotein plaques, which play a crucial role in maintaining barrier integrity. This specialized layer remains particularly vulnerable to carcinogenic influences, as constant contact with urine can harbor concentrated toxins and carcinogens, especially in the case of bladder cancer. Cigarette smoking increases the concentration of harmful substances in urine, thereby heightening the risk of urothelial carcinoma. Anti-Urothelium antibody (LBS 8) serves as an essential tool for researchers studying the complexities of bladder health and disease, providing insights into the cellular mechanisms underlying urothelial function and pathology.

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Urothelium Antibody (LBS 8) References:

1. Randomised, open-label, phase II trial of paclitaxel, gemcitabine and cisplatin versus gemcitabine and cisplatin as first-line chemotherapy in advanced transitional cell carcinoma of the urothelium.  |  Lorusso, V., et al. 2005. Oncol Rep. 13: 283-7. PMID: 15643512
2. Pemetrexed in transitional cell carcinoma of the urothelium.  |  von der Maase, H. 2004. Oncology (Williston Park). 18: 48-50. PMID: 15655937
3. Modelling cell signalling and differentiation in the urothelium.  |  Woodroffe, PJ., et al. 2005. Bull Math Biol. 67: 369-89. PMID: 15710185
4. Role of the urothelium in bladder function.  |  Wein, AJ. 2005. J Urol. 173: 2199-200. PMID: 15879891
5. Non-neuronal cholinergic system in human bladder urothelium.  |  Yoshida, M., et al. 2006. Urology. 67: 425-30. PMID: 16461116
6. Contractile activity of ATP and diadenosine tetraphosphate on urinary bladder in the rats: role of superoxide anion and urothelium.  |  Khattab, MM. and Al-Hrasen, MN. 2006. Auton Autacoid Pharmacol. 26: 149-56. PMID: 16553643
7. The physiological function of the urothelium--more than a simple barrier.  |  Lazzeri, M. 2006. Urol Int. 76: 289-95. PMID: 16679827
8. Gemcitabine in the treatment of advanced transitional cell carcinoma of the urothelium.  |  Bellmunt, J., et al. 2006. Ann Oncol. 17 Suppl 5: v113-7. PMID: 16807437
9. Induction of human embryonic and induced pluripotent stem cells into urothelium.  |  Osborn, SL., et al. 2014. Stem Cells Transl Med. 3: 610-9. PMID: 24657961
10. Monoclonal antibodies to human urothelial cell lines and hybrids: production and characterization.  |  Trejdosiewicz, LK., et al. 1985. J Urol. 133: 533-8. PMID: 2579255
11. Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.  |  d'Emmanuele di Villa Bianca, R., et al. 2015. PLoS One. 10: e0136859. PMID: 26368121
12. Development, regeneration and tumorigenesis of the urothelium.  |  Wiessner, GB., et al. 2022. Development. 149: PMID: 35521701

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Urothelium Antibody (LBS 8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Urothelium Antibody (LBS 8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Urothelium Antibody (LBS 8) Specifications

Alternate Product Name: Urothelium

Product Clone Name: LBS 8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Urothelium

Epitope Species: human

Product Reactivity/Detection: Urothelium

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Urothelium Antibody (LBS 8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin