urocortin III Antibody (C3): sc-517449

Urocortin III Antibody (C3) is a mouse monoclonal IgG2a kappa light chain antibody that detects urocortin III protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-urocortin III antibody (C3) is available as the non-conjugated format. Urocortin III, a member of the corticotropin-releasing hormone (CRH) family, plays a crucial role in regulating stress responses and appetite. Urocortin III is primarily expressed in the brain, particularly in the midbrain, as well as in the heart, pituitary gland, adrenal gland, gastrointestinal tract, ovary, spleen, and kidney. Urocortin III localization in the brain suggests direct involvement in modulating behaviors related to feeding, anxiety, and auditory processing. Urocortin III acts as a specific ligand for the CRF type 2 receptor, which mediates stress-coping responses, highlighting urocortin III importance in neuroendocrine regulation of stress. Synthetic human urocortin III has shown high-affinity binding to CRH receptors and can stimulate adrenocorticotropic hormone (ACTH) release from dispersed rat anterior pituitary cells in vitro. Urocortin III gene is located on human chromosome 2, emphasizing urocortin III relevance in human physiology and potential implications in stress-related disorders.

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urocortin III Antibody (C3) References:

1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.  |  Ames, RS., et al. 1999. Nature. 401: 282-6. PMID: 10499587
2. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor.  |  Hsu, SY. and Hsueh, AJ. 2001. Nat Med. 7: 605-11. PMID: 11329063
3. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.  |  Lewis, K., et al. 2001. Proc Natl Acad Sci U S A. 98: 7570-5. PMID: 11416224
4. Urocortin III-immunoreactive projections in rat brain: partial overlap with sites of type 2 corticotrophin-releasing factor receptor expression.  |  Li, C., et al. 2002. J Neurosci. 22: 991-1001. PMID: 11826127
5. Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior.  |  Vetter, DE., et al. 2002. Nat Genet. 31: 363-9. PMID: 12091910
6. Urocortin III is expressed in pancreatic beta-cells and stimulates insulin and glucagon secretion.  |  Li, C., et al. 2003. Endocrinology. 144: 3216-24. PMID: 12810578
7. Expression of urocortin III/stresscopin in human heart and kidney.  |  Takahashi, K., et al. 2004. J Clin Endocrinol Metab. 89: 1897-903. PMID: 15070962
8. Urocortins as cardiovascular peptides.  |  Takahashi, K., et al. 2004. Peptides. 25: 1723-31. PMID: 15476939
9. Urocortin 3 function in glucose metabolism.  |  Greenhill, C. 2022. Nat Rev Endocrinol. 18: 333. PMID: 35414022
10. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor.  |  Vaughan, J., et al. 1995. Nature. 378: 287-92. PMID: 7477349
11. Cloning and characterization of human urocortin.  |  Donaldson, CJ., et al. 1996. Endocrinology. 137: 2167-70. PMID: 8612563
12. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide.  |  Spina, M., et al. 1996. Science. 273: 1561-4. PMID: 8703220

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-urocortin III Antibody (C3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-urocortin III Antibody (C3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

urocortin III Antibody (C3) Specifications

Alternate Product Name: urocortin III

Product Clone Name: C3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 22-161

Epitope Target: urocortin III

Epitope Species: human

Product Reactivity/Detection: urocortin III

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 1% glycerol, and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for urocortin III Antibody (C3): N/A