Date published: 2026-1-26

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urocortin III Inhibitors

Urocortin III inhibitors belong to a specialized chemical class designed to modulate the biological activity of urocortin III, a neuropeptide that functions as a member of the corticotropin-releasing factor (CRF) family. Urocortin III is primarily associated with the regulation of stress responses, playing a crucial role in various physiological and behavioral processes. The inhibitors within this chemical class are carefully engineered molecules that specifically target and bind to urocortin III, disrupting its normal signaling pathways. By interfering with the interaction between urocortin III and its respective receptors, these inhibitors aim to exert a regulatory influence on the downstream cellular and molecular events triggered by urocortin III activation.

urocortin III inhibitors possess distinct molecular features that enable them to bind selectively to the urocortin III peptide, stopping its binding to its cognate receptors. This selectivity is paramount in ensuring that the inhibitors do not interfere with the activities of other closely related peptides within the CRF family. Through their targeted inhibition, these compounds hold potential in unraveling the intricate signaling cascades associated with urocortin III, shedding light on its diverse physiological functions. Understanding the pharmacological nuances of urocortin III inhibitors may pave the way for a deeper comprehension of stress-related mechanisms and unveil novel avenues for scientific exploration in the realm of neurobiology and endocrinology.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Antalarmin hydrochloride

220953-69-5sc-203820
sc-203820A
10 mg
50 mg
$186.00
$640.00
1
(0)

Antalarmin is a non-peptide CRF receptor antagonist that binds to the CRF1 receptor, preventing the action of urocortin III by blocking its binding site.

3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine

195055-03-9sc-498264
10 mg
$380.00
(0)

Also called R121919, this compound is a CRF1 receptor antagonist that can inhibit the effects of urocortin III by blocking receptor activation.